马钱子碱对豚鼠心脏乳头肌动作电位的影响  

Effect of brucine on the action potentials in guinea pig papillary muscles

作　　者：李明华[1,2,3] 赵德华[1,2,3] 张贵卿[1,2,3] 

机构地区：[1]新乡医学院药理教研室 [2]河南医科大学一附院神经内科 [3]河南医科大学药理教研室

出　　处：《中国药理学通报》1997年第2期157-159,共3页Chinese Pharmacological Bulletin

摘　　要：研究马钱子碱对心肌电生理方面的影响。采用常规微电极技术同步记录收缩力的方法，观察了马钱子碱对豚鼠心脏乳头肌动作电位（Ａｐ）及收缩力（Ｆｃ）的影响。实验结果表明：马钱子碱在浓度大于等于１×１０－６ｍｏｌ·Ｌ－１时，浓度依赖地延长快反应动作电位（ＦＡＰ）及高钾除极组织胺和氯化钡诱发的慢反应动作电位ＳＡＰ的ＡＰＤ５０、ＡＰＤ９０，在浓度大于等于３×１０－６ｍｏｌ·Ｌ－１时，抑制ＦＡＰ及ＳＡＰ的Ｆｃ，在浓度大于等于１×１０－５ｍｏｌ·Ｌ－１时，还可抑制ＦＡＰ及ＳＡＰ的ＡＰＡ、Ｖｍａｘ。提示马钱子碱具有阻断心肌Ｋ＋、Ｎａ＋、Ｃａ２＋通道的作用。To study the effects of brucine on cardiac electrophysiology, using a standard microelectrode technique, recording the action potentials (AP) and contractile force (Fc) simultaneously. It was demonstrated that brucine dose dependently increased the action potential duration at 50% and 90% repolarization of the fast action potential (FAP) and the BaCl 2 or histamine induced slow action potential (SAP) at or more than 1×10 -6 mol·L -1 . When perfused with brucine at or more than 3×10 -6 mol·L -1 , the Fc of the preparations was suppressed. At or more than 1×10 -5 mol·L -1 , brucine decreased the APA and V max of the FAP and SAP. The results suggested that brucine probably block the K +, Na + and Ca 2+ channels.

关 键 词：马钱子碱 乳头肌 动作电位 心肌收缩力 马钱子 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]