蛇毒纤溶酶的体内过程及药物代谢动力学研究  

Pharmacokinetic Studies of Nevin Fibrinolytic Enzyme

作　　者：沈子龙[1,2] 汪笑菲 廖志勇 王红 李晓祥 

机构地区：[1]中国药科大学生物技术研究中心 [2]兆峰科大药业有限公司

出　　处：《中国药科大学学报》1997年第2期107-110,共4页Journal of China Pharmaceutical University

摘　　要：以１２５Ｉ－蛇毒纤溶酶作示踪剂对蛇毒纤溶酶的体内过程及药代动力学进行了研究。实验结果表明，静脉注射后，大鼠体内血药浓度时程曲线为二房室模型，Ｔ１／２β分别为６．１ｈ（低剂量），６．３ｈ（中剂量）和５．６ｈ（高剂量）。小鼠尾静脉注射后３ｈ，各脏器中放射性活性达到峰值，其值（％）大小顺序如下：肾（１．３４）＞肺（（１．０９）＞肝（０．９０）＝脾（０．９０）＞心（０．５１）＞肌肉（０．４５）＞脑（０．２９）。１２５Ｉ－蛇毒纤溶酶主要从尿排泄，静脉注射后，７２ｈ内尿排泄率达８５．６％，而粪排泄仅为５．４％，胆汁排泄率为１２％。The pharmacokinetics of nevin fibrinolytic enzyme (NFE) was studied by 125 I NFE as a tracer Experiment results have showed that the time concentration curve mainly was fitted to a two compartment model after i.v, and its T 1/2β were 6 1 h (0 02 u/kg),6 3 h(0 04 u/kg) and 5 6 h(0 08 u/kg) respectively. The 125 I NFE was found to be distributed widely in organs of mice after iv, the peak concentration of 125 I NFE in organs appeared at 3 h, and its values were as follows:1 34% (kidney), 1 09%(lung), 0 90%(liver), 0 90%(spleen), 0 51%(heart), 0 45%(muscle) and 0 29%(brain) The 85 6% of 125 I NFE was excreted in urine and only 5 4% in feces in 72 h after iv The percentage of gall excretion in rats was 12 in 8h after iv.

关 键 词：蛇毒纤溶酶 药物代谢动力学 

分 类 号：R973.2[医药卫生—药品]