^(99m)Tc-DTPA雾化吸入检测肺泡清除功能及初步分析  

Measurement and analysis of alveolar clearance using 99m Tc DTPA radio aerosol

作　　者：杜建强 曾世荃[1,2] 程木华[1,2] 吴克宁[1,2] 胡平[1,2] 李沂[1,2] 李春亿[1,2] 石锐[1,2] 

机构地区：[1]广州市肿瘤医院核医学科 [2]中山医科大学附属第一医院核医学科

出　　处：《中华核医学杂志》1997年第2期74-76,共3页Chinese Journal of Nuclear Medicine

摘　　要：为探讨检测肺泡清除功能的方法以及肺泡清除功能变化的可能机理，应用９９ｍＴｃＤＴＰＡ雾化吸入２～３分钟后，启动γ相机连续动态采集３０分钟，以前５分钟的曲线斜率为Ｋ１，５分钟后的曲线斜率为Ｋ２。结果：正常对照组的时间放射性曲线为单室模型曲线，Ｙ＝Ａｅ－ｋｔ，在半对数坐标上为近似斜线，Ｋ１＝（９０８±４７９）×１０－３，Ｋ２＝（７３５±３２５）×１０－３（ｘ±ｓ）；吸烟、甲亢和哮喘组的Ｋ１、Ｋ２均高于正常（ｔ值３１６４～１０２３０，Ｐ＜００１），为双室或三室以上的多室模型曲线。结果表明：上肺与中肺的Ｋ１有显著差异，Ｋ１是一个灵敏指标。各病变组呼吸膜改变的主要原因是肺泡上皮或毛细血管内皮受损所致。PURPOSE To establish a method for measurement and analysis of alveolar clearance using radio aerosol METHODS Subjects breathed the aerosol quietly for 2～3min, then acquisited with γ camera for 30min The slope of curve in the first 5min as K 1 and K 2 after 5min were calculated RESULTS The normal 99m Tc DTPA pulmonary time activity curve best fit a curve of single compartment model (Y=Ae -kt ) K 1=(9 08±4 79)×10 -3 ,K 2=(7 35±3 25)×10 -3 (±s) In smoking, hyperthyroidism and asthma groups, K 1 and K 2 were significantly higher than those in normals (t=3 164～10 230, P<0 01), and fit the curve of multi compartment model CONCLUSIONS K 1 was more sensitive than K 2, and K 1 of apical lung was more useful than K 1 of middle one The reason for this was that capillary endothelium or/and alveolar epithlium were damaged

关 键 词：DTPA 锝99M 气雾剂 肺泡清除功能 

分 类 号：R817.441[医药卫生—影像医学与核医学]