培哚普利对孤立性房颤患者P波离散度的影响  

Effect of perindopril on the P wave dispersion in patients with isolated paroxymal atrial fibrillation

作　　者：许冬秀[1] 郭晖[1] 周利平[1] 纪翠玲[1] 刘俊法[1] 白冰[1] 

机构地区：[1]哈尔滨医科大学第一临床医院心内科,150001

出　　处：《临床心电学杂志》2007年第3期172-173,共2页Journal of Clinical Electrocardiology

摘　　要：目的研究培哚普利对孤立性阵发性房颤患者P波离散度(Pd)、血管紧张素Ⅱ、左房内径及房颤复发的影响。方法将54名孤立性阵发性房颤患者随机分为治疗组及对照组,每组27例。治疗组给予培哚普利4mg/d,1次/日,对照组给予比索洛尔50mg/d,早晚各25mg。两组在治疗前及治疗后3个月分别测定P波最大时限(Pmax)、Pd、血管紧张素Ⅱ、左房内径,并观察治疗期间两组房颤发生的次数。结果培哚普利组可使Pmax和Pd明显减小(p<0.05),使血管紧张素Ⅱ明显降低(p<0.01),使左房内径稍有缩小(p>0.05)。对照组虽也使Pmax、Pd减小但差异不显著(p>0.05),对血管紧张素Ⅱ及左房内径几乎无影响(p>0.05)。培哚普利组房颤发生的次数明显减少(p<0.01),而对照组虽也有减少,但差异不显著(p>0.05)。结论培哚普利能够减小孤立性房颤的Pmax和Pd,降低血管紧张素Ⅱ水平,减少房颤的发生次数及发作时间,而且使左房有缩小的趋势。培哚普利能改变心房的结构异常和电生理异常。Objective To investigate the effect of perindopril on Pd,ANG Ⅱ ,LAD and recurrent of AF in patients with isolated paroxymal atrial fibrillation （IPAF）. Methods 54 patients with IPAF were randomly divided into two groups ,test group and control group （n=27 in each group） .We treated the test group with perindopril 4mg/d, once time per-day,and the control group with bisoprolol 50mg/d, 25mg n＆m.We determined the Pmax,Pd, ANG Ⅱ,LAD of the two groups at pre-treatment and post-treatment.We also observed the frequency of AF of the two groups during the stage of therapy. Results The perindopril could decrease the Pmax and Pd（p〈0.05）, it could reduce the level of ANG Ⅱ obviously（p〈0.01）, it decrease LAD slighfly（p〉0.05）.Though, the control group can also decrease the Pmax and Pd, no difference between two groups（p〉0.05）,it has almost no effect on ANG Ⅱ and LAD. The perindopril group can reduce the incidence of AF obviously （p〈0.01）.The control group also reduce the incidence of AF, but no difference （p〉0.05）. Conclusion Perindopril can decrease the Pmax and Pd of IPAF and the level of ANG Ⅱ, reduce the incidence and episode times of AF, and it had the tendency to reduce the left atrium. Perindopril can change the structural and electrophysiologic abnormality of atrium.

关 键 词：培哚普利 孤立性房颤 P波离散度 

分 类 号：R541.75[医药卫生—心血管疾病]