海洛因依赖者的脑部MRI表现  

MRI Manifestations of Brain in the Heroin-Dependent Patients

作　　者：张建军[1] 胡臣文[2] 董汉彬[2] 王建国[2] 申大光[2] 马钦华[2] 

机构地区：[1]深圳市公安局强制戒毒所,广东深圳518019 [2]深圳市罗湖区人民医院影像中心

出　　处：《实用放射学杂志》2007年第6期731-733,共3页Journal of Practical Radiology

基　　金：深圳市卫生科技计划项目(编号:200304220)

摘　　要：目的探讨无明显神经系统症状的海洛因依赖者的脑部磁共振改变。方法将30例无明显神经系统症状的海洛因依赖者按吸毒时间分为3组,分别为<4年组(12例)、4～8年组(10例)和>8年组(8例)。所有患者均进行常规MRI检查,包括T1WI、T2WI及FLAIR序列,分析不同吸毒时间组海洛因依赖者的脑部MRI表现。结果在MRI图像上,<4年组无异常发现,4～8年组有2例、>8年组有4例分别出现大脑半球脑白质内多发斑点状异常信号灶,统计学分析>8年组与<4年组比较有显著性差异(P<0.05)。而且,吸毒时间越长,脑萎缩趋势越明显。结论随吸毒时间的延长,海洛因依赖者会出现脑白质的损伤及脑萎缩改变。Objective To study the MRI changes of brain in the heroin - dependent patients without apparent neurological symptoms. Methods 30 heroin - dependent patients without apparent neurological symptoms were divided into 3 groups according to the time of drug - abuse, i.e. 〈 4 years（group A, 12 cases） , 4 -8 years（group B, 10 cases） and 〉 8 years（group C,8 cases） respectively. All cases underwent MRI examinations including T1WI, T2WI and FLAIR. MRI manifestations of different groups were analyzed. Results On MRI, noabnormal appearance was found in group A, multiple mottling abnormal signals in the cerebral white matter were found in 2 cases in group B and 4 cases in group C. The significant difference between group C and group A was found by statistical analysis（ P 〈 0.05 ） , and with the drug - abuse time prolonged, the cerebral atrophy became more conspicuously. Conclusion With the drug - abuse time prolonging, the lesions of the cerebral white matter and the atrophy of brain will be appeared in the heroin - dependent patients.

关 键 词：脑 海洛因 磁共振成像 

分 类 号：R996[医药卫生—毒理学] R322.81[医药卫生—药学]