胶原酶结合臭氧治疗腰椎间盘突出症临床观察  

Therapeutic Effect of Collagenase and Oxygen-Ozone in Patients with Lumbar Disc Herniation

作　　者：陈旭昌[1] 吴智群[1] 王执民[1] 李中华[1] 

机构地区：[1]第四军医大学唐都医院介入放射科,陕西西安710038

出　　处：《实用放射学杂志》2007年第6期819-820,827,共3页Journal of Practical Radiology

摘　　要：目的评价胶原酶结合臭氧治疗腰椎间盘突出症的疗效。方法对临床及CT或MRI确诊的腰椎间盘突出症90例,随机分2组,A组给予硬膜外前间隙注射胶原酶,B组在A组基础上椎间盘内注射臭氧。结果术后3个月随访,A组45例:显效率37.8%,有效率93.3%;B组45例:显效率68.9%,有效率95.6%,B组较A组疗效明显提高(P<0.05)。2组均无明显不良反应。结论胶原酶和臭氧联合治疗腰椎间盘突出症疗效满意。Objective To evaluate the clinical effect of chemonucleolysis with collagenase and oxygen - ozone in lumbar disc herniation. Methods 90 cases with lumbar disc herniation confirmed by clinic, CT or MRI were randomly divided into the control group （ collagease was injected outside the lumbar disc） and treatment group （ based on the treatment of control group, oxygen - ozone was injected into lumbar disc）. Results 90 cases were followed - up after the operation for 3 months. The excellent rate was 37.8% in the control group, 68.9% in the treatment group. The excellent or good rate was 93.3% in the control group, 95.6% in the treatment group. The excellent rate was significantly higher in the treatment group than that in the control group （ P 〈 0. 05 ）. Conclusion The therapeutic effect using collagenase combined with ozone to treat lumbar disc herniation is satisfactory.

关 键 词：胶原酶 臭氧 化学溶解术 腰椎间盘突出症 

分 类 号：R681.53[医药卫生—骨科学] R815[医药卫生—外科学]