甲状腺过氧化物酶抗体在自身免疫性甲状腺疾病中的表现  

Thyroid peroxidase antibody in autoimmune thyroid diseases

作　　者：赵树君[1] 田恩江[1] 孙富军[1] 陈祖培[1] 

机构地区：[1]天津医科大学内分泌研究所免疫室,300070

出　　处：《中华内分泌代谢杂志》2007年第3期251-252,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助重点项目(30230330);天津市科技发展计划项目(05YFGDSF02700);天津市高等学校科技发展基金项目(2004ZD08)

摘　　要：甲状腺功能亢进(甲亢)、甲状腺功能低下(甲低)和亚临床甲低患者甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)和甲状腺微粒体抗体(TMAb)的阳性率和阳性患者的抗体水平均高于正常对照组,TPOAb阳性率在各组中又明显高于同组的TGAb和TMAb阳性率。甲状腺功能恢复正常的复诊组TPOAb阳性患者的抗体水平明显低于甲亢组、甲低组和亚临床甲低组。提示TPOAb对自身免疫性甲状腺疾病的诊断、治疗及预后评估具有一定的临床意义。In hyperthyroid, hypothyroid and subclinical hypothyroid patients, the positive rate and level of the thyroid autoantibodies were all remarkably higher than those in the control group. The positive rate of thyroid peroxidase antibody （TPOAb） was higher than those of thyroglobulin antibody and thyroid microsome antibody in each group. In the group with restored thyroid function, the average level of TPOAb was significantly decreased, suggesting that TPOAb could be taken as an important indicator in evaluating the treatment and prognosis of autoimmune thyroid diseases.

关 键 词：甲状腺炎 自身免疫性 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 

分 类 号：R581[医药卫生—内分泌]