在长期高脂喂养大鼠阻断肾素血管紧张素系统对内脂素基因表达的影响  

The effect of blockade of rennin angiotensin system on expression of visfattn mRNA in long term high fatfed rats

作　　者：齐翠娟[1] 袁莉[1] 李新[1] 徐国玲[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌

出　　处：《中华内分泌代谢杂志》2007年第3期273-274,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：湖北省自然科学基金资助(No:2005ABA158)

摘　　要：内脂素(visfatin)是新近发现的一种脂肪因子,具有类似胰岛素的作用。本研究显示,长期高脂喂养大鼠内脂素的表达与肥胖和胰岛素抵抗相平行。阻断肾素血管紧张素系统后,内脂素表达降低,胰岛素抵抗现象改善。内脂素可能在胰岛素抵抗的发生中起重要作用。Visfatin was recently reported as an adipokine and was found to exert insulin-mimicking effects. The results showed that the expression of visfatin parallelled with obesity and insulin resistance in long term high fat chow-fed rats. The expression of visfatin mRNA was decreased and the insulin resistance improved after rennin-angiotensin system was blocked. Visfatin may play an important role in the pathogenesis of insulin resistance.

关 键 词：胰岛素抵抗 内脂素 肾素-血管紧张素系统 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]