男性Ⅱ型糖尿病患者胰岛素敏感性与性激素结合球蛋白浓度相关性研究  

The relationship between insulin sensitivity and plasma sex hormone binding globulin level in male NIDDM patients

作　　者：胡蜀红[1] 蔡仕林[1] 

机构地区：[1]武汉同济医科大学附属同济医院内分泌科

出　　处：《中国糖尿病杂志》1997年第2期95-98,共4页Chinese Journal of Diabetes

摘　　要：以初次诊断未经治疗的１９例男性Ⅱ型糖尿病患者为研究对象，以空腹血糖（ＦＰＧ）与空腹胰岛素（ＦＩＮＳ）浓度乘积的倒数作为胰岛素敏感性指数（ＩＳＩ），分析ＩＳＩ与年龄、腰臀围比（ＷＨＲ）、体重指数（ＢＭＩ）、性激素结合球蛋白（ＳＨＢＧ）以及睾酮（Ｔ）的相关性，结果发现ＩＳＩ与ＳＨＢＧ呈极显著性正相关（ｒ＝０．５６，Ｐ＝０．０１）。在以ＩＳＩ为因变量，以年龄、ＷＨＲ、ＢＭＩ、ＳＨＢＧ和Ｔ为自变量的逐步回归分析中，只有ＳＨＢＧ进入方程（β＝０．７８，Ｐ＝０．００５）。从而说明男性Ⅱ型糖尿病患者血浆ＳＨＢＧ水平能在一定程度上反映胰岛素敏感性的高低。Nineteen newly diagnosed and untreated male NIDDM patients were studied. The reverse of the product of fasting plasma glucose(FPG) and fasting insulin concentration(FINS) was calculated as insulin sensitivity index(ISI). The relation of ISI to age, body mass index(BMI), waist hip ratio(WHR), sex hormone binding globulin(SHBG) and plasma total testosterone level(T) was analysed respectively. In pearson correlation analysis, ISI was positively correlated with SHBG(r=0 56,P=0 01). The multiple stepwise linear regression analysis demonstrated that SHBG was the only predictor of ISI(β=0.78,P=0 005). In conclusion,this study suggests that plasma SHBG level in NIDDM patients can reflect the insulin sensitivity in certain degree.

关 键 词：糖尿病 胰岛素依赖型 性激素 结合球蛋白 男性 

分 类 号：R587.102[医药卫生—内分泌]