两种短效达必佳方案在控制超排卵中的疗效比较  

Comparison of two different protocols by short-acting triptorelin in controlled ovarian hyperstimulation.

作　　者：杨隽[1] 王树玉[1] 马延敏[1] 

机构地区：[1]首都医科大学附属北京妇产医院生殖医学中心,北京100006

出　　处：《中国优生与遗传杂志》2007年第2期92-93,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的比较两种短效达必佳方案在控制超排卵中的治疗效果。方法回顾性分析2004年1月~2005年12月在本生殖中心接受体外受精-胚胎移植（IVF-ET）黄体中期长方案者130例,将启动日（月经第2~3d）促黄体生成素（LH）〈2 IU/L者分为A、B两组,A组患者自启动日起停止使用达必佳,使用促性腺激素（Gn）促排卵,B组患者继续使用达必佳至绒毛膜促性腺激素（HCG）注射日,其余同A组,比较两组的治疗效果。结果A组的促性腺激素（Gn）用量明显少于B组（28.25±6.33支vs 30.86±7.44支,P〈0.05）;Gn使用时间、HCG注射日的血P、E2、LH水平及获卵率、受精率、卵裂率、妊娠率两组间均无显著性差异。两组均无内源性LH峰出现。结论对启动日LH〈2 IU/L的患者给予停止达必佳的使用,可抑制内源性LH峰的出现,并能减少Gn用量及治疗费用。To compare the efficacy of two different protocols by short - acting triptorelin in controlled ovarian hyperstimulation. Methods： The outcome of 130 patients who performed in vitro fertilization -embryo transfer （IVF -ET） during the period of 2004. 01 - 2005.05 were retrospectively analyzed. These patients received long term protocol whose LH 〈 2IU/L on the day 2 of the cycle when gonadotropin starting, were divided into two groups： triptorelin stopped in group A while triptorelin were continued in group B till hCG＇s injection. The dose of gonadotripin, the hormone levels on the hCG injection day, the number of ova obtained, fertilization rate and clinical pregnancy rate were studied. Results： No premature endogenous LH surge occurred in either group. The age of patients, infertility years, the number of ova obtained, fertilization rate and clinical pregnancy rate between the two groups had not shown significant difference, while the dose of gonadotropin used in group A was lower than that of group B （28. 25 -＋ 6. 33 vs 30. 86 ＋ 7.44, P 〈 0.05 ）. Conclusion ： Lower dose of triptorelin used in IVF treatment achieved same effectivenes as full dose of triptorelin, resulting in reduction of the gonadotropins and the cost of treatment.

关 键 词：体外受精-胚胎移植 达必佳 控制下超排卵 

分 类 号：R714.8[医药卫生—妇产科学]