脂微球前列腺素E_1与硫酸镁在肺心病急性期的疗效观察  

The Therapeutic Effect on Liposomal Prostaglandin E1 and Magnesium Sulfate to the Cor Pulmonale Acute Exacerbation Stage

作　　者：谢玉宝[1] 郭敏军[1] 韩洁韵[1] 李道海[1] 梁子敬[1] 

机构地区：[1]广州医学院第一附属医院急诊科,广州510120

出　　处：《现代生物医学进展》2007年第7期1068-1069,1075,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨脂微球前列腺素E1注射液(Lipo-PGE1)和硫酸镁注射液联用对肺心痛急性加重期的临床疗效及作用机制。方法:将2004-06～2005-05广州医学院第一附属医院急诊科留观室收治的53例肺心病急性加重期患者,随机分为治疗组28例,对照组25例。2组均给予低流量吸氧、祛痰止咳、抗感染、解痉平喘、强心利尿等常规治疗,治疗组在常规治疗基础上加用脂微球前列腺素E_1注射液10ml、25%硫酸镁注射液10ml,疗程2周。观察2组患者治疗后临床症状改善状况及治疗前后血气分析的改变。结果:2组患者临床疗效总有效率分别为89.5%和74.2%,治疗组疗效优于对照组(x^2=1.87,P<0.05);两组患者PaO_2、PaCO_2、SaO_2治疗后均有效改善,且治疗组血气分析各项观察指标的改善优于对照组(P<0.05)。结论:脂微球前列腺素E_1注射液和硫酸镁注射液联用,能降低肺动脉压,减轻右心室后负荷,扩张气管平滑肌、改善通气障碍,可改善肺心病急性加重期的PaO_2、PaCO_2,对肺心病急性加重期有较好的临床疗效。Objective： To explore the clinical therapeutic effect and mechanism of liposomal prostaglandin E1 injection and magnesium sulfate injection allied together on patients who are in the acute exacerbation stage of cor pulmonale. Methods： 53 patients who were in the acute exacerbation stage of cor pulmonale in the emergency department of The Affiliated Hospital of Guangzhou Medical College 2004-06～2005-05 were randomly separated into two parts. 28 patients were in therapy group and the other 25 patients were in control group. Both two groups accepted the same roudne therapy such as low discharge absorb oxygen, dispel phlegm to stop coughing, antiinfection, strong heart and diureses etc. The patients in therapy group received routine therapy combined with intravenous at a dosage of 10μg Liposomal prostaglandin E1 and at a dosage of 10 mls 25% magnesium sulfate injection, treated once a day for 2 weeks. To observe two group patients＇ clinical symptom （include cough, expectoration, cardiopalmus, anhelation, heart function rid moist rales et al） improving on post-treatment. The prior-treatment and posr-treatment on the blood gas analysis were observed. Results： The clinical therapeutic effect of therapy group and control group distinguished to 89.5% and 74.2%, therapy group＇s therapeutic effect was much better than comparison group （x^2=-1.87, P〈0.05 ）. Two groups of patients had improve utility after post-treatment on blood gas analysis, and the blood gas analysis＇ observation indexing of the therapy group was better than control group too （AP〈0.05）. Compared with control group, the therapy group significantly increased the PaO2 level and saturation of blood oxygen level （PaO2 of therapy group from 8.36±2.28 to 10.52±2.12kPa, PaO2 of control group from8.27±1.92 to 9.15±1.83kPa. SaO2 of therapy group is 89±7%/and SaO2 of control group is 76±7%）. But the PaCO2 level was significantly decreased （PaCO2 of therapy group fromg.31±3.41kPa to 7.63±1.62 kPa and PaCO2 of control group

关 键 词：脂微球前列腺素E1注射液 硫酸镁注射液 肺心病 

分 类 号：R541.5[医药卫生—心血管疾病]