原发性高血压病患者颈动脉粥样硬化程度与血清胆红素水平的相关性研究  

The relation between serum bilirubin and carotid artherosclerosis in patients with hypertension

作　　者：贺涛[1] 李杰[1] 陶建虹[1] 

机构地区：[1]四川省人民医院心内二科,成都610072

出　　处：《中国实用神经疾病杂志》2007年第4期2-4,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨高血压病患者颈动脉粥样硬化程度与血清胆红素水平的关系。方法158例高血压病患者行双侧颈动脉超声多普勒检查,根据检测结果分为颈动脉粥样硬化组和正常颈动脉组。记录各组年龄、性别、体重指数、吸烟史、糖尿病史和血压,测定血清总胆红素及其他生物化学指标。结果颈动脉粥样硬化组的血清总胆红素水平(8.37±3.53)μmol/L显著低于正常颈动脉组(14.53±4.61)μmol/L(P<0.05)。多因素回归分析显示:低胆红素血症与颈动脉粥样硬化呈显著正相关(χ2wald=4.41,P=0.029,OR=3.72)。结论低胆红素血症是高血压病患者发生颈动脉粥样硬化的独立危险因素。Objective To explore the relationship between serum bilirubin level and severity of carotid atherosclerosis in patients with hypertension. Methods 158 patients with hypertension whose bilateral carotid arteries were detected by ultrasound were divided into ＇carotid atherosclerosis group and normal group. Their age, sex, BMI, smoking history, diabetes history and blood pressure were recorded. Serum bilrubin and other biochemical indicators were detected. Results Carotid atherosclerosis group had a significantly lower serum bilirubin than normal group （8.37 ± 3.53）, （14. 53 ± 4. 61） （P〈0. 05）. Muliple regression analysis （Logistic） showed the low serum bilirubin were correlated with carotid atherosclerosis（X^2 wald= 4. 41, P= 0. 029, OR=3. 72）. Conclusion The low serum bilirubin is the independent risk factor in carotid atherosclerosis patients with hypertension.

关 键 词：高血压病 血清胆红素 颈动脉粥样硬化 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病] R543.4[医药卫生—内科学]