Ni电极电化学流通池检测四环素类药品的研究  

Determination of Tetracyclines Based on the Flow-through Electrochemical Detection Cell with Nickel Electrode

作　　者：潘丹梅[1] 胡荣宗[1] 韦冬萍[1] 丁昊冬[1] 

机构地区：[1]厦门大学化学系现代分析科学教育部重点实验室,福建厦门361005

出　　处：《电化学》2007年第2期122-126,共5页Journal of Electrochemistry

基　　金：国家自然科学基金(No.20527005)资助项目

摘　　要：比较Au、GC和Ni电极对四环素的电化学响应,讨论了纯Ni电极对四环素的电催化氧化特性,提出以纯Ni为工作电极的电化学流通池,优化结构,建立了测定四环素类抗生素的电化学流通池安培检测法.该方法对四环素、土霉素和强力霉素都有较高的响应灵敏度,线性范围0.1～15mg/L.最低检出限分别为35、45和43μg/L.用此方法可以直接测定四环素类药品的含量.The electrochemical responses to tetracycline at the nickel electrode in alkaline solution were compared with that of gold and glassy carbon electrode by vohammetry. The electrocatalytic oxidation characteristics of tetracycline at nickel electrode were discussed. Subsequently a flow-through amperometric detection cell with nickel as the working electrode was designed to detect tetracycline, oxytetracycline, and doxycycline. Standard calibration graphs for the tetracyclines yielded linear ranges of 0.1 - 15 mg/L. Detection limits （ S/N = 3） of 35, 45 and 43 μg/L were obtained for tetracycline, oxytetracycline and doxycycline, respectively. The system was applied for the determination of the three antibiotics in single-component drug formulations.

关 键 词：锞电极 四环素 电催化氧化 电化学流通池 

分 类 号：R927[医药卫生—药学]