谷氨酰胺诱导热休克蛋白对急性肺损伤的保护作用  

Glutamine induces heat shock proteins to protect against acute lung injury

作　　者：梁梦凡[1] 王学敏[1] 江伟[1] 

机构地区：[1]上海交通大学第六人民医院麻醉科,上海200233

出　　处：《上海交通大学学报（医学版）》2007年第1期114-116,共3页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：热休克蛋白的表达对急性肺损伤(ALI)有保护作用,而以往的诱导药物大多有毒有害,限制了其临床应用。谷氨酰胺能够诱导热休克蛋白表达,对ALI和脓毒症产生保护作用,具有潜在的临床应用价值。The expression of heat shock proteins （HSPs） can protect against acute lung injury（ALl）. However, HSPs are restrained from clinical application due to the toxicity of most of the former inductors. Glutamine, which also has the ability to induce the expression of HSPs, can protect against ALl and sepsis, and may serve as a candidate for clinical application.

关 键 词：热休克蛋白 急性肺损伤 谷氨酰胺 

分 类 号：R563.8[医药卫生—呼吸系统]