B细胞稳态的信号调节  

Signal Regulation of B Cell Homeostasis

作　　者：赵庆欢[1] 陈元鼎[1] 

机构地区：[1]中国医学科学院,中国协和医科大学医学生物学研究所,云南昆明650118

出　　处：《生物技术通讯》2007年第1期103-106,共4页Letters in Biotechnology

摘　　要：在人类,65%的骨髓产生的B细胞是自身反应性的,它们大部分在骨髓中被克隆删除了。但有些B细胞通过免疫无力的方式逃脱了这种克隆删除到达外周,产生抗自身的抗体。研究表明,在鼠和人类中,B细胞存活时间过长是引发自身性免疫病的原因之一。B细胞的过度活化将导致自身反应性B细胞的产生和破坏自身免疫耐受,引起自身免疫性疾病或肿瘤;但B细胞的活化不足将使B细胞数量大大减少,抗原应答能力降低,从而使适应性免疫应答失衡。细胞因子和其他信号分子对B细胞稳态的调节是十分严密的,它们或调节B细胞的发育、成熟和分化,或调节B细胞向外周的迁移,或通过调节B细胞周期而使B细胞停留在特定时期,从而使B细胞避免凋亡,或通过调节抗凋亡蛋白或凋亡蛋白而决定B细胞的生存或死亡。本文就细胞因子、转录因子、蛋白激酶等信号分子对B细胞稳态的调节做一综述。Approximately 65% of B cells generated in human bone marrow are autoreactive B cells. Most of these cells are clonally deleted in the bone marrow, but some of these cells avoid deleting and escape to periphery by anergy and produce autoantibody. Recent studies suggest that extended B lymphocyte survival is a cause of autoimmune disease. B cell over activate results in proliferation autoreactive B cell and impairing self tolerance, leads to autoimmune disease and B cell lymphoma. Contrast, insufficiency stimulation leads to decrease the number of B cells, attenuated B cell response to antigen and the adaptive immune response was pertarbated. Cytokine and other signal molecules play many roles in regulating B cell homeostasis, include B cell proliferation, maturation, differentiation, migration to periphery. Some molecule control the cell cycle and make B cell arresting in specific phase consequential the B cell avoids apoptosis, others regulation anti-apoptosis or apoptosis protein to determine B cells survival or death. Here we make a review to discussion about the cytokine, transcription factor, protein kinase and other signal molecules regulate B cell homeostasis.

关 键 词：B细胞 稳态 信号调节 BAFF 

分 类 号：R392.1[医药卫生—免疫学]