普罗布可对冠心病患者血清中MMP-2的抑制作用  

Inhibitory effect of Probucol on expression of serum matrix metalloproteinase 2 in patients with coronary heart disease

作　　者：郝冰[1] 孟晓萍[1] 杨东华[2] 王莉[1] 郭昊[3] 

机构地区：[1]吉林大学第二医院心内科,吉林长春130041 [2]吉林大学第二医院动物室,吉林长春130041 [3]吉林省梅河口市友谊医院

出　　处：《吉林大学学报（医学版）》2007年第3期559-561,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题(20050408-5)

摘　　要：目的:探讨抗氧化剂普罗布可对冠心病患者血清中基质金属蛋白酶原2(pro-MMP-2)、基质金属蛋白酶2(MMP-2)的抑制作用。方法:采用明胶酶谱法和酶法测定30例冠心病患者普罗布可治疗前及治疗1个月后静脉血pro-MMP-2、MMP-2及血清胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)的水平。结果:冠心病患者药物治疗后pro-MMP-2、MMP-2、TC、LDL-C较治疗前降低,上述各指标治疗前后比较差异均具有显著性(P<0.05)。药物治疗前后HDL-C、TG比较差异均无显著性(P>0.05)。结论:普罗布可在降低血清TC、LDL-C的基础上,对基质金属蛋白酶有抑制作用,提示普罗布可可作为一种稳定斑块的基质金属蛋白酶抑制剂应用于临床。Objective To study the inhibitory effects of Probucol on the expressions of serum promatrix metalloproteinase-2 （pro-MMP-2） and matrix metalloproteinase-2 （MMP-2） in patients with coronary heart disease （CHD）. Methods The levels of serum Pro-MMP-2 and MMP-2 were detected by zymograph and total cholesterol （TC）, triglyeeride （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） were measured by enzyme method in 30 CHD patients before and after treatment with Probueol. Results After treatment of Probueol, the expression levels of pro-MMP-2, MMP-2, TC and LDL-C in serum were decreased than those before treatment, respeetively; there were obvious differences of various indexes mentioned above between before and after treatment （P〈0. 05）. The expression levels of HDL-C and TG in serum had no significant difference between before and after treatment （P〉0.05）. Conclusion Probueol can inhibit the expressions of pro-MMP-2 and MMP-2 in serum as same as TC and LDL-C. Probueol, as one of TIMPs, may be applied to stabilize plaque..

关 键 词：普罗布可 明胶酶A 冠状动脉硬化 动脉粥样斑块 

分 类 号：R541.4[医药卫生—心血管疾病] R453[医药卫生—内科学]