时间分辨荧光免疫分析法检测乳腺疾病患者血清CA15-3、CEA的临床意义  

Clinical significance of CA15-3 and CEA detection in mammary gland diseases with time-resolved fluoroimmunoassay technique

作　　者：魏丽琴[1] 孙文伟[1] 田鸿钧[2] 孙步彤[3] 马庆杰[1] 

机构地区：[1]吉林大学中日联谊医院核医学科,吉林长春130033 [2]吉林大学中日联谊医院乳腺-甲状腺外科,吉林长春130033 [3]吉林大学中日联谊医院血液肿瘤科,吉林长春130033

出　　处：《吉林大学学报（医学版）》2007年第3期584-586,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅自然科学基金资助课题(200505165)

摘　　要：目的:评价时间分辨荧光免疫分析(TRFIA)技术检测血清CA15-3、CEA在乳腺疾病诊断与治疗中的应用价值。方法:应用TRFIA技术检测正常对照组(57例)、乳腺增生组(206例)、乳腺良性肿瘤组(136例)、乳腺癌无复发或无转移组(89例)及乳腺癌复发或转移组(39例)患者血清CA15-3、CEA含量。结果:血清CA15-3、CEA含量,正常对照组、乳腺增生组、乳腺良性肿瘤组3组间比较差异均无显著性(P>0.05),但乳腺癌无复发或无转移组含量均明显高于前3组(P<0.05),乳腺癌有复发或转移组术前均明显高于前3组(P<0.01)及乳腺癌无复发或无转移组术前(P<0.05);乳腺癌术后3个月与前3组比较差异均无显著性(P>0.05),但均明显低于乳腺癌无复发或无转移组术前(P<0.05)及乳腺癌有复发或转移组(P<0.01)。结论:无创伤性血清CA15-3可作为乳腺疾病性质、术后疗效判定及随访的指标。Objective To evaluate the application values of time-resolves fluroimmunoassay （TRFIA） technique for CA15-3 and CEA detection in mammary gland diseases. Methods TRFIA was used to detect the serum concentrations of CA15-3 and CEA in normal control group （n= 57）, hyperplasia group （n= 206）, benign mammary neoplasm group （n= 136）, mammary cancer with out recurrence or metastasis group （n= 89） and mammary cancer with recurrence or metastasis group （n= 39）. Results There were no significant differences of CA15-3 and CEA serum concentrations between control group, mammary hyperplasia group and benign mammary neoplasm group （P〉0.05）. However, the CA15-3 and CEA concentrations in mammary cancer without recurrence or metastasis group were significantly higher than those in the former three groups （P〈0. 05）. Also, the CA15-3 and CEA concentrations in mammary cancer with recurrence or metastasis group were remarkably higher than those in the former three groups （P〈0. 01） and mammary cancer without recurrence or metastasis group （P〈0.05）. While CA15-3 and CEA concentrations in the 3-month post-operation group showed no significant difference with those in the former three groups （P〈0.05）, though, were distinctly lower than those in the mammary cancer without or with recurrence or metastasis groups （P〈0. 05, P〈0.01）. Conclusion The atraumatic detection of CA15-3 and CEA may be used as indexes in diagnosis, therapy, and curative effect estimation post-operation and following-up observation for mammary diseases.

关 键 词：CA15-3 CEA 乳腺肿瘤 

分 类 号：R655.8[医药卫生—外科学] R446.6[医药卫生—临床医学]