儿童再生障碍性贫血的分型研究  

作　　者：宁建玲[1] 黄丹丹[1] 

机构地区：[1]荣成市人民医院,山东荣成264300

出　　处：《现代保健（医学创新研究）》2007年第06X期7-9,共3页

摘　　要：目的 探讨儿童再生障碍性贫血（再障）的分型标准。方法 对已经确诊的70例儿童急性再障和51例儿童慢性再障病例进行回顾分析。结果 再障患儿有如下特点：外周血呈全血细胞减少，非造血细胞明显增多，巨核细胞明显减少，小粒细胞面积〈50％，细胞成分以非造血细胞为主；增生活跃患儿的骨髓中，非造血细胞比例明显增多，巨核细胞明显减少。慢性再障儿的特点是：外周血呈血小板减少和（或）白细胞减少和（或）贫血的血象，淋巴细胞比例增高；髂骨骨髓以增生活跃为主，但粒细胞系比例减低，红细胞系比例可正常，非造血细胞比例增高，巨核细胞减少，小粒细胞面积〈50％，细胞成分以非造血细胞为主。结论 儿童生再障的表现与Camitta提出的轻型再障不同，根据本文结果提出儿童再障的分型标准及胸骨骨髓在诊断急、慢性再障中的意义。Objective To investigate the diagnostic criteria of childhood aplastic anemia. Methods To cases of acute aplastic anemia and 51 cases of chronic aplastic anemia were analysecl retrospectively. Results A - cute aplastic anemia cases showed the following hematological features ： pancytopenia, absolute granulocytopenia and reticulocytopenia, higher percentage of lymphocyte; marrow hypoplasia with a few myeloid cells and an almost complete absence of megakaryocytes, smears revealed fatty material with diffuse, sparse accumulation of lymphocytiod cells, mast cells and plasma cells; higher percentage of non - myeloid cells and the decreased number fo megakaryocytes in the active marrow. Chronic aplastic anemia cases ：thrombocytopenia in combination with granulocytic and/or anemia in periph - eral blood; active marrow with lower percentage of granulocytic lineage, normal percentage of erythroid lineage, higher percentage of non - myeloid cells and the decreased number of megakaryocytes. Conclusion The hematological features of childhood acute aplastic anemia are similar to Camitta＇s diagnostic criteria of severe splastic anemia,while the hematological features of childhood chronic aplastic anemia is different from Camitta＇s diagnostic criteria of mild aplastic anemia. Based on these finding, a diagnostic criteria of chinldhood aplastic anemia was proposed.

关 键 词：儿童 再生障碍性贫血 分型标准 

分 类 号：R566.5[医药卫生—呼吸系统]