头孢呋新酯的多晶型研究  

Investigation of the Polymorphism of Cefuroxime Axetil

作　　者：李振华[1] 平其能[1] 朱颖[1] 柯学[1] 王海燕[1] 黄艳[1] 

机构地区：[1]中国药科大学药剂学教研室

出　　处：《中国药科大学学报》1997年第1期23-27,共5页Journal of China Pharmaceutical University

摘　　要：用不同有机溶剂重结晶制备了头孢呋新酯的多晶型，通过差热分析、红外光谱、Ｘ－射线粉末衍射法等进行鉴别，确定头孢呋新酯的晶体存在两种晶型，即低熔点晶型α和高熔点晶型β。测定了不同温度下，两晶型在０．０７ｍｏｌ／Ｌ盐酸溶液中的平衡溶解度，并计算其溶解热。The polymorphs α and β of cefuroxime axetil were prepared from different organic solvents and characterized by means of DSC、IR and X ray powder diffraction. Equilibrium solubilities were measured at five different temperatures in 0.07 mol/L HCl solution and the enthalpies were calculated. The solubilities of crystal form α at five different tempertures in 0.07 mol/L HCl solution were greater than those of crystal form β.The enthalpies of crystal form α and β were 9.64 kJ/mol and 12.04 kJ/mol,respectively.

关 键 词：头孢呋新酯 多晶型 红外光谱 

分 类 号：R978.11[医药卫生—药品]