关附庚素对缺O_2、高K^+及酸中毒豚鼠乳头肌和兔窦房结动作电位的影响  

Effects of Guanfu Base G on the Action Potential in Hypoxic, Hyperkalemic and Acidosic Guinea Pig Papllary and Rabbit Sinoatrial Node

作　　者：季慧芳[1] 张陆勇[1] 周颖[1] 郭晟 刘静涵[1] 

机构地区：[1]中国药科大学生理学教研室

出　　处：《中国药科大学学报》1997年第1期39-41,共3页Journal of China Pharmaceutical University

摘　　要：关附庚素（ＧＦＧ）０．８６μｍｏｌ／Ｌ使缺Ｏ２、高Ｋ＋和酸中毒的豚鼠乳头肌动作电位零相最大上升速率（Ｖｍａｘ）进一步降低，动作电位时程（ＡＰＤ）和有效不应期（ＥＲＰ）进一步缩短，而ＥＲＰ／ＡＰＤ９０明显增大。ＧＦＧ８，１６，１２μｍｏｌ／Ｌ使兔窦房结动作电位Ｖｍａｘ、舒张期去极化速率（ＲＤＤ）、自发活动频率（ＳＦＦ）和平均复极化速率（ＭＲＲ）显著降低，ＡＰＤ和舒张间隔（ＤＩ）明显延长。In the hypoxic, hyperkalemic and acidosic guinea pig papillary muscles, guanfu base G (GFG) 0.86 μmol/L further decreased the maximal rate of depolarization ( V max ), shortened action potential duration(APD) and effective refractory period (ERP), and had a significant increase in ERP/APD 90 ratio. When the sinoatrial nodes were exposed to GFG, their V max , rate of diastolic depolarization, spontaneous firing frequency and mean rate of repolarization were decreased, diastolic interval and APD were prolonged. Furthermore, these effects appear to be concentration dependent.

关 键 词：关附庚素 乳头肌 窦房结 动作电位 缺氧 钾离子 

分 类 号：R972.2[医药卫生—药品]