沿海居民痛风及高尿酸血症流行特点的随机、分层、整群抽样调查(英文)  

Epidemic characteristics of gout and primary hyperuricemia in Shandong coastal area: A randomized stratified cluster sampling survey

作　　者：苗志敏[1] 赵世华[1] 王颜刚[1] 李长贵[1] 王忠超[1] 陈颖[1] 陈新焰[1] 阎胜利[1] 

机构地区：[1]青岛大学医学院附属医院内分泌科,山东省青岛市266003

出　　处：《中国组织工程研究与临床康复》2007年第30期6087-6091,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：青岛市科技局攻关课题( 03-1-NY-14-1) 资助 ;国家自然科学基金课题的资助( 30470821)~~

摘　　要：背景:近年来研究发现,高尿酸血症和痛风与糖尿病、冠心病、高血压及脑血管疾病的发生和发展关系密切。对其进行深入研究和早期干预,对上述疾病一级和二级预防均有重要意义。目的:明确山东沿海20岁以上居民高尿酸血症与痛风的患病情况及其影响因素。设计:随机、分层、整群抽样调查。单位:青岛大学医学院附属医院内分泌科。对象:调查范围为山东省沿海城市,包括青岛、日照、烟台、威海、东营。抽取年龄20～80岁本地常住(≥5年)居民,以家庭为单位的自然人群为调查对象。方法:采用随机、分层、整群抽样的方法,入户调查青岛、烟台、威海、日照、东营长住居民约5000人高尿酸血症与痛风的患病情况。采用Sysmexchemix-180型全自动生化分析仪测定血尿酸、血脂、血糖、血肌酐,试剂购自日本西斯美康公司,其中血尿酸批内和批间CV分别为1.77%和2.32%。尿酸值高于正常者,在第3天再次抽空腹血进行复查。率的比较采用χ2检验,两组间均数比较用t检验,多组间均数比较用方差分析,因变量与自变量的相关分析用logistic回归分析。主要观察指标:高尿酸血症患病率、血尿酸水平、高尿酸血症患者痛风发生率,以及高尿酸血症影响因素分析结果。结果:计划调查5500人,实调查5003人,应答率为90.96%,其中男性2395人(47.87%);女性2608人(52.13%)。①高尿酸血症的患病率13.19%,按照2000年山东人口标化率为13.27%;其中男性患病率高于女性(18.32%,8.56%,χ2=108.52,P<0.01),男性发病风险为女性2.5倍(OR=2.5)。痛风的患病率为1.14%,标化率为1.10%;其中男性患病率高于女性(1.94%,0.42%,χ2=30.38,P<0.01),男性发病风险为女性5.3倍(OR=5.3)。②正常人群男性血尿酸水平高于女性[(343.40±84.54),(258.90±70.90)μmol/L,t=48.03,P<0.01]。男性高尿酸血症患者血尿酸水平明显高于女性[(469.43±48.08),(399.73±104.91)μmol/L,t=11.70,P<BACKGROUND： Recent studies have found that hyperuricemia and gout are closely correlated with the occurrence and development of diabetes, coronary heart disease, hypertension and cerebrovascular diseases. It is of significance to investigate their prevalence so as to find way of early interventions.OBJECTIVE： To determine the prevalence and risk factors of gout and hyperuricemia among residents above 20 years old in Shandong coastal area.DESIGN： A randomized, stratified cluster sampling survey.SETTING： Department of Endocrinology, Affiliated Hospital of Qingdao University Medical College.PARTICIPANTS： A random, stratified cluster sampling was conducted in Shandong coastal area including Qingdao,Yantai, Weihai, Rizhao and Dongying. Residents lived in these areas for 5 years or more, aged between 20 to 80 years, were selected, and they were surveyed by family as a unit.METHODS： A randomized, stratified cluster sampling survey was conducted. The prevalence of gout and hyperuricemia were investigated among about 5 000 residents in Qingdao, Yantai, Weihai, Rizhao and Dongying. The serum uric acid, lipids, glucose and creatinine were detected with Sysmex chemix-180 total automatic biochemical analyzer. Those with uric acid higher than reference level were reexamined by collecting fasting blood sample on the third day. The comparison between rates was taken with the Chi-square test, means between two groups with the t test, means between multiple groups with analysis of variance, correlation between dependent and independent variables with logistic regression analysis.MATN OUTCOME MEASURES： Prevalance of hyperuricemia; Level of serum uric acid; Prevalence of gout in patients with hyperuricemia; Influencing factor of hyperuricemia.RESULTS： This investigation planned to include 5 500 subjects while in fact 5 003 subjects were investigated and the response rate was 91%, in which males were 2 395 （47.87%） and females were 2 608 （52.13%）. ① The prevalence of hyperuricemia was 13.19% with standardize

关 键 词：痛风 高尿酸血症 流行病学 

分 类 号：R552[医药卫生—血液循环系统疾病]