金葵胃药对大鼠胃粘膜保护作用的实验研究  

Effect of Jin Kui Gastric Drug in Protecting Experimental Gastric Mucosal Lesion in Rat

作　　者：刘玮[1] 潮欣宜[1] 胡焕明[1] 陈化洋[1] 尹娜[1] 

机构地区：[1]淮北职业技术学院药理学教研室,安徽淮北235000

出　　处：《中国实验方剂学杂志》2007年第1期39-40,共2页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽省教育厅课题(2005KJ394ZC)

摘　　要：目的:探讨金葵胃药(JK)对大鼠胃粘膜损伤的保护作用。方法:采用阿司匹林灌胃致大鼠粘膜损伤模型,观察各实验组胃粘膜损伤指数。检测血清中肿瘤坏死因子(TNF-α)、内皮素(ET)和白细胞介素-1β(IL-1β)的含量变化。结果:JK组的胃粘膜损伤指数较模型对照组显著降低;血清中TNF-α含量下降,而IL-1β含量明显上升;ET有下降趋势,但无显著性差异。结论:JK对大鼠胃粘膜损伤具有保护作用,其机制可能与提高血清中IL-1β含量和降低TNF-α水平有关。Objective：To investigate the protective effects of Jin Kui Gastric Drug（JK） on gastric mucosal lesion in rats. Methods：The model of gastric mucosal lesion in rats was induced by aspirin, the indexes of gastric mucosal lesion in experimental groups were observed and determined respectively, the contents of tumour necrosis factor-α（TNF-α）, endothelin（ET） and interleukin-16（IL-1β） in blood serum were measured. Results：The indexes of gastric mucosal lesion after administration of JK was obviously reduced compared with model group. The coutents of TNF-α was markedly decreased and the levels of IL-1β was significantly increased. The contents of ET was also reduced, but it showed no difference between JK group and control. Conclusion：JK can protect gastric mucosal lesion in rats and its mechanism may be related to decrease in contents of TNF-α,ET and increase of the IL-1β level.

关 键 词：金葵胃药 胃粘膜 肿瘤坏死因子 白细胞介素-1Β 内皮素 

分 类 号：R285.5[医药卫生—中药学]