冬梅饮对早期糖尿病肾病大鼠肾组织非酶糖基化终产物的影响  

The Effect of DongMeiYin on Advanced Glycation end Products in the Renal Cortex of Early Diabetic Nephropathy Rats

作　　者：陈雪功[1] 周雪梅[1] 张琼玉[2] 龙子江[1] 方向明[1] 董昌武[1] 王建青[1] 

机构地区：[1]安徽中医学院,安徽合肥230038 [2]蚌埠医学院,安徽蚌埠233003

出　　处：《中国实验方剂学杂志》2007年第1期41-43,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽省教育厅;安徽中医学院临床科研基金(2003k004)

摘　　要：目的:评价中药冬梅饮(DMY)对糖尿病大鼠非酶糖基化终产物(advanced glycation end products,AGEs)的影响,探讨冬梅饮防治早期糖尿病肾病(DN)的作用机制。方法:用链尿佐菌素(STZ)建立早期DN模型,观察冬梅饮对其血糖、尿微量白蛋白(uA1b)、α1-尿微球蛋白(uα1-MG)、肾脏病理和肾皮质AGEs的影响。结果:模型大鼠的血糖、uA1b、uα1-MG和肾皮质AGEs均显著高于正常组(P<0.05或P<0.01);冬梅饮能降低模型组肾皮质AGEs(P<0.01),并明显降低uA1b、u1α-MG(P<0.05,P<0.01),改善模型大鼠的病理改变。结论:冬梅饮可抑制肾皮质中AGEs沉积,阻止DN的进一步发展。Objective：To evaluate the effects of DongMeiYin（DMY） on advanced glycation end products（AGEs） in the diabetic rats, and investigate the mechanism of preventing and treating early diabetic nephropathy（DN）. Methods： The rat early DN model was induced by injection of streptozotocin（STZ）. The changes of the blood glucose,uA1b, uα1-MG and AGEs in the renal cortex and the effects of DMY were observed. Results： The blood glucose, uA1b,uα1-MG and AGEs of the model rats were obviously increased. DMY could decrease the parameters effectively. Conclusion： DMY could inhibits the AGEs and reduce the ualb,uα1-MG, blood glucose.

关 键 词：糖尿病肾病 冬梅饮 非酶糖基化终产物 

分 类 号：R285.5[医药卫生—中药学]