益母草碱对大鼠急性心肌缺血损伤心肌肌钙蛋白T的影响  

Protective Effect of Leonurine on Acute Myocardial Ischemia Injury in Rats

作　　者：熊莺[1] 杨解人[1] 

机构地区：[1]皖南医学院药理教研室,安徽芜湖241001

出　　处：《中国实验方剂学杂志》2007年第2期21-24,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：安徽省教育厅自然科学基金项目(2003kj322)

摘　　要：目的:观察益母草碱(Leo)对大鼠急性心肌缺血损伤心肌肌钙蛋白T(cTnT)水平的保护作用。方法:采用垂体后叶素(Pit)腹腔注射法诱导大鼠急性心肌缺血,以J点(Δmv)和T波(Δmv)上移幅度评价急性心肌缺血程度;采用放免法检测血清及心肌cTnT的含量。结果:益母草碱(3,5,7,9 mg/kg)可防止Pit诱导急性心肌缺血J点及T波的抬高,并能降低血清和心肌cTnT含量(P<0.05或P<0.01),在一定剂量范围内存在量效关系。结论:Leo具有对抗垂体后叶素性急性心肌缺血损伤的作用。Objective： To investigate the protective effect of leonurine （Leo） on pituitrin （Pit）-induced acute myocardial ischemia injury in rats. Methods： Pit was administrated intraperitoneally to induce acute myocardial ischemia injury in rats. The locomotion of J point（mv） and T wave （mv） in ECG was allowed to evaluate the degree of myocardial ischemia. The content of cardiac troponin T （cTnT） in serum and myocardium was measured by radio immunoassay. Results：In Leo（3,5,7,9 mg/kg） groups, the elevation of J point and T wave was lowered. The contents of cTnT in serum and myocardium were obviously decreased. Linear regression analysis （scatterplot） indicated that there is dose-effect relationship within certain dose range. Conclusions： Leo can inhibit Pit-induced myocardial ischemia injury, with dosedependent effect.

关 键 词：益母草碱 垂体后叶素 心肌缺血 心肌肌钙蛋白T 

分 类 号：R285.5[医药卫生—中药学]