月月舒饮片汤剂与其免煎配方颗粒的指纹图谱比较  

Comparative Study on Fingerprints of Traditional Herbs Decoction and Compatible Granules of Yueyueshu by HPLC

作　　者：孔铭[1] 钱大玮[1] 鞠建明[1] 朱玲英[1] 

机构地区：[1]江苏省中医药研究院江苏省现代中药制剂工程技术研究中心,江苏南京210028

出　　处：《中国实验方剂学杂志》2007年第3期5-6,共2页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省社会发展项目(BS2003055)

摘　　要：目的:研究月月舒传统合煎液与其经过分煎制成的免煎配方颗粒混合物化学成分的差异。方法:采用HPLC色谱指纹图谱方法,比较月月舒免煎配方颗粒和月月舒汤剂两者指纹图谱的差别,并通过相似度软件分析两者的相似性。结果:月月舒配方颗粒中共出15个色谱峰,确认出其中的13个色谱峰。月月舒合煎液和混合免煎配方颗粒指纹图谱的相关系数为0.829。结论:月月舒合煎液同其分煎制成的免煎配方颗粒中的主要化学成分组成基本相同,其共有成分比例相近。Objective：To study the difference in main chemical composition between Traditional Herbs Decoction and Compatible Granules of Yueyueshu. Methods：Comparative Study on fingerprints of Traditional Herbs Decoction and Compatible Granules of Yueyuesbu by HPLC, and applied Computer Aided Similarity Evaluation to analyze similarity. Results： There were 15 peaks in the fingerprints of Compatible Granules of Yueyueshu and 13 peaks were ascertained the source. The correlation of both HPLC fingerprint was 0. 829. Conclusion： The main chemical substances and the composition＇ s ratio of Traditional Herbs Decoction and Compatible Granules of Yueyueshu were similar.

关 键 词：月月舒 配方颗粒 指纹图谱 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学]