利用改良等高线法评价甘草皂苷与桔梗皂苷合用的相互作用  

Application of Modified Isobologram Method in Quantitative Analysis for the Interaction of Saponins of Glycyrrhiza uralensis Fisch and Platycodon grandiflorum A.DC

作　　者：刘彬[1] 齐云[1] 宋杨[1] 蔡润兰[1] 王敏[1] 谢忱[1] 罗秀珍[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100094

出　　处：《中国实验方剂学杂志》2007年第3期40-42,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市自然基金资助课题(7042039);国家中医管理局资助课题(04-05ZL04)

摘　　要：目的:考查甘草皂苷与桔梗皂苷祛痰和抗炎作用的相互作用性质。方法:采用气管酚红排泌、二甲苯致耳肿胀及磷酯酶A2致足跖肿胀模型,运用改良的等高线法对两者合用的相互作用进行评价。结果:随着合用剂量的减少,相互作用评价结果呈现从拮抗到协同的趋势,在较低有效剂量范围内,表现为相加和协同的结果。结论:在固定配比下,合并效应与剂量大小密切相关。Objective：To evaluate the expectorant and anti-inflammatory effects of the combinations of saponins of Glycyrrhiza uralensis Fisch （GS） and Platycodon grandiflorum A. DC （PS）. Methods：The phenol drain model, xyleneinduced mouse ear edema model and PLA2-induced mouse paw edema model were used, and the interaction between these two agents was evaluated by modified isobologram method. Result： With the decrease of total dose, the trend of interaction from antagonism to synergism was observed, and synergism or additivity was obtained at low effective doses. Conclusion： At fixed ratio, the total dose would affect the herbal interactive effects.

关 键 词：甘草皂苷 桔梗皂苷 祛痰 抗炎 改良的等高线法 强度协同 

分 类 号：R285.5[医药卫生—中药学]