冰硼膜治疗口腔溃疡的实验研究  

Studies on the Curative Effects of Bingpeng Mo on Mouth Ulcer

作　　者：朱婉萍[1] 黄飞华[1] 孔繁智[1] 章辰芳[1] 

机构地区：[1]浙江省中医药研究院,浙江杭州310007

出　　处：《中国实验方剂学杂志》2007年第3期62-64,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察冰硼膜治疗口腔溃疡的主要药理作用。方法:采用临床常见病原菌进行冰硼膜体外抑菌试验;采用小鼠腹腔注射醋酸,观察冰硼膜对毛细血管通透性的作用;用二甲苯使小鼠耳廓肿胀,观察抗肿胀作用;采取家兔口唇黏膜涂抹碘酚溶液和家兔口腔黏膜组织匀浆作为抗原致敏动物的方法,造成家兔口腔溃疡模型Ⅰ和模型Ⅱ,观察对口腔溃疡愈合的作用;用小鼠热板法观察镇痛作用。结果:冰硼膜能有效抑制体外病原菌,显著抑制小鼠腹腔毛细血管通透性;缓解二甲苯所致小鼠耳廓肿胀;促进家兔口腔溃疡愈合;提高小鼠痛阈。结论:冰硼膜具有抑菌、杀菌、镇痛、抗肿胀及促使口腔溃疡愈合等作用。Objective： To observe the tests of Bingpeng Mo against clinical pathogen curative effects of Bingpeng Mo on mouth ulcer. Methods：The inhibition ic bacteria were done in vitro. The mice were injected intraperitoneally with acetic acid to observe Bingpeng Mo effects on the permeability of capillary vessels. The swelling ear modle of mouse was established by using xylene to study Bingpeng Mo effect of anti-swelling. The rabbit mouth ulcer model Ⅰ and modle Ⅱ were set up by smearing iodine-phenol solution onto lips and injecting the tissue homogenate of mouth mucosa as an allergen, respectively, and the functions of Bingpeng Mo on mouth ulcer were studied. The analgestic effects of Bingpeng Mo was also tested by hot plate method in mice. Results： Bingpeng Mo could effective inhibit the growing of pathogenic bacteria in vitro and inhibit the permeability of capillary vessels of mice. It could notability restrain the swelling of mice ear,accelerate rabbit＇s mouth ulcer healing and increase the pain threshold in mice. Conclusions： Bingpeng Mo have the good fuctions of bacteriostatic and bactericidal action, easing pain, anti-swelling and improving mouth ulcer.

关 键 词：冰硼膜 口腔溃疡 药效学研究 

分 类 号：R285.5[医药卫生—中药学]