冠心病和糖尿病患者血栓前状态的检测  

The study on prethrombotic state of coronary heart disease and diabetes mellitus

作　　者：谢瑞芹[1] 王凤飞[1] 都本洁[1] 李荣华[1] 张玉华[1] 宋文杰[1] 王翠霞[1] 

机构地区：[1]河北医科大学第二医院心内科,石家庄050000

出　　处：《临床心血管病杂志》1997年第2期85-87,共3页Journal of Clinical Cardiology

摘　　要：为探讨冠心病心绞痛与非胰岛素依赖型糖尿病（NIDDM）患者血栓前状态与血栓形成的关系及其机理，对20例稳定型心绞痛（SA）、26例不稳定型心绞痛（UA）、20例NIDDM、21例UA＋NIDDM患者及20例正常人的血浆vonWillebrand因子（vWF：Ag）、血浆血小板α-颗粒膜蛋白（GMP－140），血浆D-二聚体（D－Dimer）水平以及尿纤维蛋白肽A（FPA）进行检测。结果显示，不同类型的心绞痛和NIDDM及UA＋NIDDM患者以上指标均发生不同程度的变化，说明心绞痛和NIDDM等患者均有不同程度的血栓形成倾向或血栓形成。提示心绞痛和NIDDM患者可能有共同的血栓前状态的发病机理。To explore the relations and mechanism on prethrombotic state and thrombosis of angina and non-insulin-dependent diabe tes mellitus (NIDDM), the levels of plasma von Willebrand (vWF:Ag),GMP-140,D-Dimer and urine Fibrinopeptide A (FPA) were determined in hospitalized patients (20 stable angina pectoris,SA; 26 unstable angina pectoris,UA ; 20 NIDDM ; 21 UA+NiiD DM) and 20 normal controls. The results showed that different changes existed in the levels of these indexes between SA and UA and NIDDM and UA complicated NIDDM The study suggests that coronary heart disease (CHD) and NIDDM have the same pathogenesis of prethrombotic state.

关 键 词：冠心病 糖尿病 栓形成 病理学 

分 类 号：R541.402[医药卫生—心血管疾病] R587.2[医药卫生—内科学]