侧脑室注射环丙沙星对大鼠脑电和脑超微结构的影响  

Effect of intracerebroventricular injection of ciprofloxacin on electric activity and ultrastructure of brain in the rats

作　　者：陆杰[1] 钱元恕[1] 黄仲荪[1] 范维正[1] 徐晨[1] 杨素珍 

机构地区：[1]重庆医科大学生理教研室

出　　处：《中国抗生素杂志》1997年第2期136-139,共4页Chinese Journal of Antibiotics

摘　　要：以３００μｇ／ｋｇ环丙沙星注入大鼠右侧脑室后，于皮层感觉运动区记录皮层脑电图。结果：注射后分别约经１５３．９±８８．１７和２９７．８８±１２５．５５ｓ潜伏期后，右、左皮层先后出现痫样放电，以注射侧先出现。放电波形多变，频率２０～４０次／分，波幅１～２ｍＶ。同时伴有皮层、海马以细胞核损伤为主的超微结构变化。提示：环丙沙星对中枢神经系统具有刺激和损伤作用。Electrocorticogram (ECOG) were recorded in sensorimotor area of rat cortex after 300μg/kg ciprofloxacin (CPLX) injected into right ventricle of brain. The epileptiform discharge appeared at 153.90±88.17 and 297.88±125.55s in right and left cerebral cortex, respectively. Spike waves occured first at the side of injection (right lateral) and then bilaterally. The wave forms of discharge were variable. The frequency range and wave amplitude were 20￣40 spike/min and 1￣2mV, respectively. The ultra structure of cortex and hippocampus showed some injury of the nucleus. These changes were accompanied with the change of ECOG, simultaneously. The results suggested that the CPLX has a stimulating and damaging effects on the central nerve system in rats.

关 键 词：环丙沙星 脑电图 脑超微结构 

分 类 号：R978.19[医药卫生—药品]