肾脏疾病患者血脂及载脂蛋白 A_Ⅰ B_(100) C_Ⅱ的测定及其临床意义探讨  

CLINICAL SIGNIFICANCE OF DETERMINING THE SERUM LIPIDS AND APOLIPOPROTEINS A Ⅰ B 100 C Ⅱ IN GLOMERULAR DISORDERS

作　　者：郑亚莉[1,2] 吕娟[1,2] 陈虹[1,2] 李红霞 

机构地区：[1]宁夏医学院附属医院肾内科 [2]宁夏干部康复医院内科

出　　处：《宁夏医学院学报》1997年第1期4-6,共3页Journal of Ningxia Medical College

摘　　要：对２８例肾病综合征（ＮＳ），２４例慢性肾炎，１９例慢性肾衰（ＣＲＦ）及５０例健康人血脂及载脂蛋白进行了测定，结果显示：ＮＳ组和慢性肾炎组病人甘油三脂（ＴＧ）明显高于正常组（Ｐ＜０．０１）健康者，尤以ＮＳ组为著（Ｐ＜０．０５），两组高ＴＧ血症发生率分别为７５．６％和６２．５％；ＮＳ组ａｐｏＡⅠ和ＣⅡ明显升高（Ｐ＜００５和＜００１），ａｐｏＢ１００无明显变化，ａｐｏＡⅠ／ａｐｏＢ比值升高；慢性肾炎组载脂蛋白无显著变化。ＣＲＦ组高ＴＧ血症发生率为４５．６％，但其含量与正常组比较无明显改变（Ｐ＞００５）；ａｐｏＡⅠ，ａｐｏＣⅡ含量明显降低（Ｐ＜００１和＜００５），ａｐｏＢ１００明显升高（Ｐ＜００１），ａｐｏＡⅠ／ａｐｏＢ１００比值明显下降。Serum triglyceride(TG),total cholesterol(TC),and apolipoproteins(apo) A Ⅰ,B 100 and C Ⅱ were determined in 71 patients with different primary glomerular disorders and 50 healthy subjects.The result showed that significantly increased TG apoA Ⅰ apoC Ⅱ and apoA Ⅰ/apoB 100 (P<0 05 or 0.01),and nonsignificantly decreased apoB 100 (P>0 05)were found in NS group; and that nonsignificantly increased TG(>0 05),significantly decreased apoA Ⅰ apoC Ⅱ ,apoA Ⅰ/apoB 100 and apoB 100 (P<0 05 or<0 01) were found in CRF group(compared with normal group).The incidences of HTG were 75.6%,62.5% and 45.6% respectively in NS,chronic nephritis and CRF groups.

关 键 词：血脂 载脂蛋白 肾病综合征 

分 类 号：R692.02[医药卫生—泌尿科学]