幽门螺杆菌感染与儿童再发性腹痛的关系  

Study of Correlation between Helicobacter Pylori Infection and Recurrent Abdominal Pain in Children

作　　者：阮善 庄丽宝 周颖[1] 

机构地区：[1]上海市第八人民医院儿科,上海200235

出　　处：《中国临床医学》2007年第3期373-374,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:分析幽门螺杆菌感染与儿童再发性腹痛(RAP)的关系。方法:选择2004年1月—2006年8月上海市第八人民医院儿科门诊符合RAP诊断的患儿112例,以同期56例无再发性腹痛的住院患儿作为对照。采用^(13)C-尿素呼气试验检测Hp感染情况。观察Hp阳性者治疗后患儿的腹痛缓解率,并对两组临床资料进行分析。结果:RAP组与对照组的Hp感染的阳性率分别为51.8%、33.9%,两组比较有显著差异(P<0.05)。RAP的3个年龄组中,4～6岁组Hp阳性率(29.6%)显著低于7～9岁组(56.9%)和10～14岁组(65.0%)(P<0.05)。RAP组中男女的Hp阳性检出率分别是56.8%、48.5%,无显著差异(P>0.05)。喜吃零食与不喜吃零食者的Hp阳性率有显著差异(P<0.05)。RAP组58例Hp阳性患儿中49例接受抗Hp治疗,治疗后Hp阴性和阳性的腹痛缓解率分别为79.1%、33.3%,两组比较有显著差异(P<0.05)。结论:Hp感染与RAP有密切关系,可能为RAP的主要病因之一。Hp感染率随年龄增长而增高,并与不良饮食习惯(喜吃零食)有关。根治Hp治疗可缓解RAP儿童的腹痛症状。Objective：To study the correlation between helicobacter pylori infection and children with recurrent abdominal pain （RAP） . Methods： 112 medical outpatients in our hospital with recurrent abdominal pain from January 2004 to August 2006 were enrolled in for the research. 56 hospitalized children without recurrent abdominal pain during the same period were taken as the control group. ^13C-urea breath test was used to detect whether the patient got infected by helicobacter pylori and the remission rate of children with RAP when the bacteria was eradicated. Also the age,sex, bad eating habits of children with RAP were compared. Results： The positive rate of helicobacter pylori infection between the RAP group and the control group was 51.8%,33.9% respectively. Among 4-6yr age group,7-9 yr age group and 10-14yr age group with RAP the positive rate of Hp infection was 29.6% ,56.9% ,65.0% ,4-6yr age group was lower than another age groups（P〈0.05）. The positive rate between male and female was 56.8 %,48.5 %. No significant difference with sex（P〉0.05）, but the significant difference was exsisted with eating habits （P〈0.05） was found. There was significant difference between the two groups（P〈0.05）. 49 cases of 58 Hp-positive children with RAP got therapy. The lysis rate of abdominal pain in Hp-negative group was 79.1 % while the rate in Hp-positive group was 33.3% with significant difference between the two groups （P〈0.05）. Conclusion： There is a closed relation between Hp infection and RAP. Hp infection may be the main cause of RAP. The proportion of HP infection increased with the growth of ages and related eating habits,such as eat snacks frequertly. Helicobacter pylori eradication therapy can alleviate the symptoms of abdominal pain in children.

关 键 词：幽门螺杆菌 再发性腹痛 

分 类 号：R725.7[医药卫生—儿科]