A Novel Toxicological Evaluation of TiO2 Nanoparticles on DNA Structure0  

作　　者：朱融融 汪世龙 张蕤 孙晓宇 姚思德 

机构地区：[1]School of Life Science and Technology, Tongji University, Shanghai 200092, China

出　　处：《Chinese Journal of Chemistry》2007年第7期958-961,共4页中国化学（英文版）

摘　　要：TiO2 has been tested to be toxic to DNA under the photo-irradiation of ultraviolet A （UVA）. However, in the dark conditions, after several days of treatment with TiO2 in aqueous solution, the interaction between TiO2 and two types of DNA was detected and the mechanisms were studied by the methods of gel-electrophoresis, IR spectroscopy and TEM. The results showed that the DNA would be bound to TiO2; the ratio of binding was related to the concentration and the treating time; the mechanism of binding is related to phosphate groups of DNA. Besides, DNA with different structure showed different degree of binding. These findings showed a new possible way through which the TiO2 nanoparticles interact with DNA.TiO2 has been tested to be toxic to DNA under the photo-irradiation of ultraviolet A （UVA）. However, in the dark conditions, after several days of treatment with TiO2 in aqueous solution, the interaction between TiO2 and two types of DNA was detected and the mechanisms were studied by the methods of gel-electrophoresis, IR spectroscopy and TEM. The results showed that the DNA would be bound to TiO2; the ratio of binding was related to the concentration and the treating time; the mechanism of binding is related to phosphate groups of DNA. Besides, DNA with different structure showed different degree of binding. These findings showed a new possible way through which the TiO2 nanoparticles interact with DNA.

关 键 词：TiO2 nanoparticle DNA damage phosphate group binding 

分 类 号：R991[医药卫生—毒理学]