L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction： an Environment-friendly Method for the Synthesis of β- Hydroxyl keto nes  

作　　者：彭以元 刘汉 崔明 程津培 

机构地区：[1]Key Laboratory of Green Chemistry, Jiangxi Province and Department of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330027, China [2]Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China [3]Key Laboratory of Poyang Lake Ecological Environment and Resource Development, Jiangxi Normal University, Nanchang, Jiangxi 330027, China

出　　处：《Chinese Journal of Chemistry》2007年第7期962-967,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20342007, 20462003, 20452001 and 20421202）.

摘　　要：An environment-friendly L-prolinamide catalyzed aldol reaction has been developed. The reaction exhibited broad substrate generality, and high yields with good diastereoselectivity were obtained for cyclic ketones.The simplicity of product isolation, usage of water as environmentally benign reaction medium, and the usage of cheap, readily available and recyclable catalyst make this process promising to be developed for large-scale preparation of β-hydroxyl ketones.An environment-friendly L-prolinamide catalyzed aldol reaction has been developed. The reaction exhibited broad substrate generality, and high yields with good diastereoselectivity were obtained for cyclic ketones.The simplicity of product isolation, usage of water as environmentally benign reaction medium, and the usage of cheap, readily available and recyclable catalyst make this process promising to be developed for large-scale preparation of β-hydroxyl ketones.

关 键 词：aldol reaction L-prolinamide β-hydroxylketone green chemistry 

分 类 号：O623.511[理学—有机化学]