微波促进的5-氯-3-甲基-1-苯基-4-吡唑甲醛与氯化N-苯乙酮基吡啶及芳酰肼的缩合反应  

Microwave Irradiated Condensation Reaction of 5-Chloro-3-methyl-1-phenyl-4-pyrazolecarboaldehyde with N-Phenacylpyridinium Chloride and Acetophenone

作　　者：张奉民[1] 蔡习美[1] 陈伟锋[1] 颜朝国[1] 

机构地区：[1]扬州大学化学化工学院分析测试中心,扬州225002

出　　处：《有机化学》2007年第7期852-856,共5页Chinese Journal of Organic Chemistry

基　　金：江苏省教育厅自然科学基金(No.04KJD150237)资助项目.

摘　　要：5-氯-3-甲基-1-苯基-4-吡唑甲醛(1)在微波辐射下,与氯化N-苯乙酮基吡啶(2)和取代苯乙酮3在醋酸铵/醋酸体系中一锅煮反应,高产率地生成了吡唑基取代的吡啶衍生物4a～4e.1与芳酰肼在微波辐射下反应,则形成了酰腙类化合物6a～6g.1与羟胺在微波辐射下缩合可生成肟7a和腈7b的混合物.In the system of ammonium acetate and acetic acid under microwave irradiation, 5-chloro-3- methyl-1-phenyl-4-pyrazolecarboaldehyde （1） reacted with N-phenacylpyridinium chloride （2） and acetophenone 3 to give pyrazolyl substituted pyridine 4a～4e in high yields. 1 reacted with some aromatic acyl-hydrazines 5 to give acylhydrazone derivatives 6a～6g, while reacted with hydroxyamine to give a mixture of oxime 7a and nitrile 7b.

关 键 词：微波辐射 缩合反应 吡啶 吡唑 酰腙 

分 类 号：O621.25[理学—有机化学]