Effects of fufang yimucao oral liquid on acute ache model mice  

作　　者：Fengjie Wang Mingsan Miao Yulin Zhang Jingjing Shi Yalei Yang Huili Liu 

机构地区：[1]Department of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, Henan Province, China

出　　处：《Neural Regeneration Research》2007年第6期372-375,共4页中国神经再生研究（英文版）

基　　金：New Century Excellent Person Project of Ministry of Education; No. NCET-04-0657;Cultivating Project of Advanced School Innovate Person of Henan Province,No. 2004-23

摘　　要：BACKGROUND： Fufang yimucao oral liquid has markedly effects on ameliorating circulation, restraining uterine constriction induced by oxytocin, alleviating dysmenorrhea, as a traditional medicine on promoting blood circulation by removing blood stasis, yimucao could ameliorate abnormal hemorrheological when hemorrhagic shock happens, enhance the hemoperfusion of organs and actively react on the result of hemorrhagic shock. OBJECTIVE： To investigate the abirritation offufang yimucao oral liquid on pain model mice induced by hot board method and acetic acid twist body method and dysmenorrhea model mice induced by estradiol. DESIGN： Entirely randomly grouping and control experiment. SETTING： Pharmacological Laboratory, Henan College of Traditional Chinese Medicine. MATERIALS： A total of 200 female Kunming genus mice of grade 2 and weighing 18- 21 g were collected. Fufang yimucao oral liquid, mainly consist ofyimucao, danggui, chuanxiong, muxiang, and so on, was produced by Henan Joyline ＆ Joysun Pharmaceutical Stock Co., Ltd. （batch number： 050701）; yimucao oral liquid was produced by Shangqiu Lvyuan Pharmaceutical Co., Ltd. （batch number： 050108）; estradiol slice by Shanghai Xinyi Kangjie Pharmaceutical Co., Ltd. （batch number： 050301）; YSL-6A intelligence hot plate instrument by Shandong Equipments Station of the Medical Science. METHODS： The experiment was carried out in the Animal Experiment Center of the Henan College of Traditional Chinese Medicine from August to November 2005. The high-, middle- and low-dosage fufang yimucao oral liquid in the experiment was 1, 0.5 and 0.25 in volume fraction, respectively, andyimucao oral liquid was 0.5. ① Among 80 mice, 60 mice were eligible in pain threshold tested by hot plate, and randomly dividing into 5 groups with 12 in each group. Mice in the high-, middle- and low-dose fufang yimucao oral liquid groups were perfused with 1 mL, 0.5 mL and 0.25 mL/mLfufang yimucao, and mice in the yimucao group and saline group were perfused with the sBACKGROUND： Fufang yimucao oral liquid has markedly effects on ameliorating circulation, restraining uterine constriction induced by oxytocin, alleviating dysmenorrhea, as a traditional medicine on promoting blood circulation by removing blood stasis, yimucao could ameliorate abnormal hemorrheological when hemorrhagic shock happens, enhance the hemoperfusion of organs and actively react on the result of hemorrhagic shock. OBJECTIVE： To investigate the abirritation offufang yimucao oral liquid on pain model mice induced by hot board method and acetic acid twist body method and dysmenorrhea model mice induced by estradiol. DESIGN： Entirely randomly grouping and control experiment. SETTING： Pharmacological Laboratory, Henan College of Traditional Chinese Medicine. MATERIALS： A total of 200 female Kunming genus mice of grade 2 and weighing 18- 21 g were collected. Fufang yimucao oral liquid, mainly consist ofyimucao, danggui, chuanxiong, muxiang, and so on, was produced by Henan Joyline ＆ Joysun Pharmaceutical Stock Co., Ltd. （batch number： 050701）; yimucao oral liquid was produced by Shangqiu Lvyuan Pharmaceutical Co., Ltd. （batch number： 050108）; estradiol slice by Shanghai Xinyi Kangjie Pharmaceutical Co., Ltd. （batch number： 050301）; YSL-6A intelligence hot plate instrument by Shandong Equipments Station of the Medical Science. METHODS： The experiment was carried out in the Animal Experiment Center of the Henan College of Traditional Chinese Medicine from August to November 2005. The high-, middle- and low-dosage fufang yimucao oral liquid in the experiment was 1, 0.5 and 0.25 in volume fraction, respectively, andyimucao oral liquid was 0.5. ① Among 80 mice, 60 mice were eligible in pain threshold tested by hot plate, and randomly dividing into 5 groups with 12 in each group. Mice in the high-, middle- and low-dose fufang yimucao oral liquid groups were perfused with 1 mL, 0.5 mL and 0.25 mL/mLfufang yimucao, and mice in the yimucao group and saline group were perfused with the s

关 键 词：Fufangyimucao oral liquid twisting body response DYSMENORRHEA model 

分 类 号：R984[医药卫生—药品]