银杏叶注射液对炎症反应综合征患者血浆细胞因子的影响  

Effect of Folium Ginkgo Iniection on Plasma Cytokines in Patients with Systemic Inflammatotory Response Syndrome

作　　者：吴锦鸿[1] 许国根[1] 陈雯[1] 缪群[1] 裘力峰[1] 顾清[1] 黄卫东[2] 

机构地区：[1]杭州市第一人民医院,杭州310006 [2]浙江大学医学院附属邵逸夫医院

出　　处：《浙江中西医结合杂志》2007年第7期398-399,402,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨银杏叶注射液对全身炎症反应综合征(SIRS)患者细胞因子的影响。方法:符合SIRS诊断48例,随机分成银杏叶注射液治疗(治疗组)和常规治疗(对照组)。分别在治疗前和治疗后第1、3、5天清晨空腹抽肘静脉血3ml,测定肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-1(IL-1)和C反应蛋白(CRP)。结果:治疗组TNF-α、IL-6、IL-1含量,治疗后第1天明显低于治疗组,治疗后各观察点持续降低(P<0.05,P<0.01);血浆CRP水平治疗后第1天有下降,但与对照组比较,差异无显著性意义(P>0.05),治疗后第3天、第5天与对照组比较差异有显著性意义(P<0.05、P<0.01)。结论:银杏叶注射液治疗SIRS患者,可降低TNF-α、IL-6、IL-1等细胞因子和CRP水平,能干预机体的过度炎症反应。Objective,To investigate the effect of folium ginkgo injection on plasma cytokines in patients with systemic inflammatory response syndrome（SIRS）. Methods：48 cases of SIRS were randomly divided into the treatment group and the contrast group. The treatment group was treated by fohum ginkgo and the contrast group by routine medicine. 3ml blood was drawn from elbow vein with empty stomach before therapy, at the 1 st, 3rd, and 5th day after therapy respectively, and the levels of TNF IL-6 ,IL-1 and CRP were measured. Results：At the 1st day after therapy,the levels of TNF-α,IL-6 and IL-1 in the treatment group were obviously lower than those in the contrast group and persisted faUing during the therapy （ P 〈 0. 05 ,P 〈0.01 ）. At the 1st day after therapy the decrease of CRP Ievel in the treatment group had no significant difference from that in the contrast group （ P 〉 0.05 ）. From the 3rd day the level of CRP in tile treatment group decreased rapidly and had a significant difference from that in the contrast group （ P 〈 0. 05,P 〈 0. 01 ）. Conclusion： Folium ginkgo injection can reduce the level of TNF-α, IL-6, IL-1 and CRP and intervene in the excess inflamlnatory response.

关 键 词：全身炎症反应综合征 银杏叶注射液 细胞因子 C反应蛋白 

分 类 号：R278[医药卫生—中医学]