补体在缺血再灌注损伤中的作用及机制  

Role and mechanism of complement in ischemia reperfusion injury

作　　者：谭兵[1] 张德纯[2] 汪正清[1] 

机构地区：[1]第三军医大学微生物学教研室,重庆400038 [2]重庆医科大学临床检验诊断学省部共建教育部重点实验室病原生物学教研室,重庆400016

出　　处：《创伤外科杂志》2007年第4期374-376,共3页Journal of Traumatic Surgery

基　　金：国家自然科学基金资助项目(30471723)

摘　　要：补体系统在缺血再灌注时通过多种途径被激活,形成大量的活化片段。这些片段在缺血再灌注损伤中发挥着重要作用,它们通过直接作用和对白细胞与内皮细胞的间接作用造成组织器官损伤。目前抗补体的药物虽较多,但真正用于临床的十分有限。笔者现就缺血再灌注时补体的激活途径,活化补体成分引起损伤的作用机制及防治研究进展综述如下。Complement system is activated by all kinds of pathways in ischemia reperfusion （I/R） , which re-suits in the formation of many activated fragments. These fragments play an important role in ischemia reperfusion injury. Through direct attack and indirect influence on neutrophil and vascular endothelium ,tissue and organ are in-jured by them. There are a lot of inhibitors of complement at present,however,few of which was applied clinically. The author now give an review on the pathways of complement activation in I/R, mechanism of activated complement components mediated tissue injury and prevention and treatment using complement inhibitors in I/R injury.

关 键 词：补体 补体激活 缺血再灌注损伤 

分 类 号：R37[医药卫生—病原生物学]