妊娠期肝内胆汁淤积症胎盘组织缺氧诱导因子HIF-1α、HIF-2α mRNA表达水平的研究  

Expression of HIF-1α mRNA and HIF-2α mRNA in Placentas of Pregnant Women with Intrahepatic Cholestasis of Pregnancy

作　　者：胡雅毅[1] 王晓东[1] 刘淑芸[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041

出　　处：《四川大学学报（医学版）》2007年第4期641-643,共3页Journal of Sichuan University(Medical Sciences)

基　　金：国家教委博士点基金(20020610030)资助

摘　　要：目的观察缺氧诱导因子-1α(HIF-1α)mRNA、缺氧诱导因子-2α(HIF-2α)mRNA在妊娠期肝内胆汁淤积症(ICP)患者胎盘组织上的表达,探讨其与ICP胎儿缺氧的关系。方法ICP患者和正常晚孕妇女各20例,RT-PCR法检测两组胎盘组织上HIF-1αmRNA、HIF-2αmRNA的表达。结果ICP患者胎盘组织HIF-1αmRNA、HIF-2αmRNA的表达和正常晚孕妇女差异均无统计学意义(P>0.05)。结论低氧条件下,ICP患者胎盘组织HIF蛋白合成的调节可能并不在mRNA表达水平,而在转录后水平。Objecti pregnant women with in pregnant women with IC ve To investigate the expression of HIF-1α mRNA and HIF-2α mRNA in placentas of trahepatic cholestasis of pregnancy（ICP）. Methods Twenty samples of placentas from P and 20 samples of normal term placentas were selected. The expression levels of HIF-1α mRNA and HIF-2αmRNA were measured by RT-PCR. Results There was no statistically significant difference in respect to the expression levels of HIF-1α mRNA and HIF-2αmRNA between the two groups of samples （P〉0. 05）. Conclusion Under hypoxic conditions, HIF-1α and HIF-2α proteins are not transcriptionally regulated at the mRNA level but are probably regulated at the post-mRNA level.

关 键 词：妊娠并发症 胆汁淤积 肝内 缺氧诱导因子 mRNA 

分 类 号：R714.25[医药卫生—妇产科学]