SOCS1与T细胞分化发育及功能调控的研究进展  

Advances in SOCS1 and its regulation on proliferation, differentiation and functions of T lymphocyte

作　　者：郑媛媛[1] 

机构地区：[1]第二军医大学免疫学研究所,上海200433

出　　处：《国际免疫学杂志》2007年第4期228-232,共5页International Journal of Immunology

摘　　要：细胞因子参与介导了机体天然免疫和获得性免疫应答反应，SOCS家族是近年来发现的通过JAK／STAT途径抑制细胞因子信号转导通路的负性调控蛋白。目前SOCS家族成员中以SOCS1的研究最为深入。SOCS1的缺失会导致T细胞胸腺选择受阻，以IFNγ为主的多种细胞因子的过量分泌，T细胞表面活化分子表达增加等等。因此，SOCS1的正常表达对于T细胞的分化发育和自身稳定发挥了重要作用。Cytokines are key regulators of the immune system that shape innate and adaptive immune responses. The suppressor of cytokine signaling （SOCS） family members form a classical negative feedback circuit of cytokine-induced signal transduction by JAK-STAT pathway. At present, SOCS1 has been studied most thoroughly among SOCS family members, Loss of SOCS1 results in blockage of both positive and negative selection of T lymphocyte in thymus, over-secretion of many cytokines especially IFNγ and increased expres- sion of many active molecules on T cells. Therefore, the normal expression of SOCS1 plays an important role in proliferation, differentiation, and homeostasis of T cells.

关 键 词：细胞因子 SOCS1 负性调控蛋白 T细胞 信号转导 

分 类 号：R3[医药卫生—基础医学]