TCRβ链CDR3谱序与疾病研究概况及进展  

Study of the spectratyping of CDR3 length of TCR beta chain in diseases

作　　者：姚新生[1] 

机构地区：[1]遵义医学院免疫学教研室

出　　处：《国际免疫学杂志》2007年第4期240-244,共5页International Journal of Immunology

基　　金：国家自然科学基金资助（30660172）

摘　　要：近年来，T细胞受体（TCR）互补决定区（CDR）和机体的生理、病理关系研究取得了较大的进展，尤其是在超抗原作用的感染性疾病、自身免疫性疾病、肿瘤等疾病状态下，TCRB链CDR3谱型能很好地反映T细胞的功能，通过TCRβ链CDR3谱型来研究克隆性和寡克隆性增生T细胞，可了解T细胞免疫与疾病发生发展的关系，指导疾病的诊断及免疫治疗，同时可了解正常情况下T细胞的发生和发展情况。Recently, numerous reports have highlighted the restriction of the CDR3 length of TCR beta chain in many diseases ,the CDR3 length of TCR beta chain can reflect the function of T cells, especially in the infection diseases with super antigen, autoimmune diseases, solid tumors and hematological malignancies. By detailing analysis of the CDR3 spectratyping of TCR beta T cells might be interesting to light on the further study of the individualized of related diseases and it would be helpful in exploring new immunological pathogeneses and facilitating the design of the diseases, as well as in improving our understanding of healthy human T-cell development.

关 键 词：免疫扫描谱型分析 CDR3 自身免疫性疾病 超抗原 肿瘤 

分 类 号：R3[医药卫生—基础医学]