活化性受体NKG2D及其配体的研究进展  

Research and development of activatory receptor NKG2D and its ligands

作　　者：郑为东[1] 

机构地区：[1]重庆医科大学附属第二医院骨科,400010

出　　处：《国际免疫学杂志》2007年第4期262-265,共4页International Journal of Immunology

摘　　要：NK细胞是肌体免疫系统至关重要的组成部分，其表达多种活化性和抑制性细胞表面受体。NKG2D是较为独特的活化性受体，属C型凝集素家族跨膜蛋白，分布较广，NK细胞、T细胞和其他免疫细胞都可以产生，其配体具有多样性，MHCⅠ类相关分子（MIC）是人类NKG2D识别的配体之一，应激性表达在一些肿瘤细胞或病原体感染细胞的表面。NKG2D既能直接活化NK细胞，又能以协同刺激的方式促进CD8^＋αβT细胞的活化，在抗肿瘤免疫和病毒感染等方面发挥重要作用。NK ceils are crucial components of the innate immune system, which express multiple activating and inhibitory cell-surface receptors. NKG2D is a distinct activatory receptor which belongs to C-type lectin and is found on NK cells but is also widely expressed on T cells and other immune system cells. NKG2D recognizes multiple diverse ligands , and MHC- Ⅰ related molecule is one of the ligands for human NKG2D, which is stressfully expressed in most tumours or pathogen-infected tissue cells. NKG2D mediates costimulation in CD8^ ＋ αβT cells and/or activation in NK cells, furthermore, it is involved in lysis of tumors and plays a critical role in the innate immune response against virus infections.

关 键 词：NKG2D 自然杀伤细胞 NKG2D配体 

分 类 号：R3[医药卫生—基础医学]