SARS疫苗研究进展  

Research progress on SARS vaccine

作　　者：曾玉红[1] 

机构地区：[1]中国医学科学院基础医学研究所、中国协和医科大学基础医学院免疫室硕士研究生,北京100005

出　　处：《国际免疫学杂志》2007年第4期266-269,共4页International Journal of Immunology

摘　　要：2003年世界性的流行病——严重急性呼吸综合症（SAILS）引发了各国科学家对SARS相关冠状病毒（SARS-Coy）的研究热潮。SARS-Coy是一种新的冠状病毒，其致病机制还不清楚，目前尚无有效治疗SARS的抗病毒药物，研制一种安全有效的疫苗是阻止SARS再次流行最有效的方式。目前研究较多且有发展前景的SARS疫苗有：灭活疫苗、DNA疫苗和表位疫苗等。但在SARS疫苗的研究过程中也遇到了很多问题，如没有标准的动物模型、SARS-Coy变异快等问题。所以，研发一种安全有效的SARS疫苗任重而道远。The emergence of the severe acute respiratory syndrome （SARS） that resulted in a pandemic in 2003 spurred a flurry of interest in the SARS associated coronavirus （SARS-Cov）. SARS-Cov is a new member of coronavirus, whose pathogenisis is still not clear. Now there is no effective anti-viral agent available for SARS treatment. The development of safe and effective vaccines is considered to be one of the best ways to prevent another SARS epidemic. At present, potential vaccine candidates under development include inactivated SARS vaccine, DNA vaccine, and epitope-based vaccine. However, there exist many difficulties in the development of SARS vaccines, for example, lack of an animal model that mimics human disease, frequent variation of SARS-Cov and so on. As a consequence, the development of an effective and safe SARS vaccine shoulders heavy responsibilities.

关 键 词：SARS 冠状病毒 SARS-Coy 疫苗 动物模型 

分 类 号：R3[医药卫生—基础医学]