G蛋白对神经细胞电压依赖性离子通道的直接调制作用  

Direct Modulatory Effects of G Proteins on Voltage Dependent Ion Channels of Nerve Cells

作　　者：吴新生[1] 何淑舫[1] 

机构地区：[1]中国科学院上海脑研究所

出　　处：《生理科学进展》1997年第1期14-18,共5页Progress in Physiological Sciences

摘　　要：神经递质对神经细胞电压依赖性离子通道具有调制作用。近年来观察到，神经递质可通过Ｇ蛋白介导对神经细胞电压依赖性离子通道直接发挥调制作用，而不经过目前已知的多种第二信使的介导，使人们对递质、Ｇ蛋白与电压依赖性离子通道间的相互关系有了新的认识。本文归纳了神经递质通过Ｇ蛋白对电压依赖性通道的直接调制的表现。Neurotransmitters have regulative effects on voltage dependent ion channels of nerve cells. Recent studies have shown that voltage dependent channels were modulated by transmitters through direct interactions between G proteins and channels without any known second messengers being involved.This gave us a novel understanding of the relations between G proteins and voltage dependent ion channels.This article reviews the phenomena, characteristics, and mechanisms about voltage dependent channels modulated by transmitters through direct effects of G proteins.

关 键 词：神经递质 G蛋白 电压依赖性通道 调制 离子通道 

分 类 号：Q422[生物学—神经生物学] R338[生物学—生理学]