人类细胞色素P450与药物氧化代谢遗传多态性分子机制的研究现状  

Study of the Molecular Mechanism of Human Cytochrome P450 and Genetic Polymorphism of Drug Oxidative Metabolizing Enzyme

作　　者：赵莉[1] 楼雅卿[1] 

机构地区：[1]北京医科大学基础医学院药理学系

出　　处：《生理科学进展》1997年第1期35-40,共6页Progress in Physiological Sciences

摘　　要：近年，在表型及基因型水平上均发现存在药物氧化代谢多态性，特别是对于人类细胞色素Ｐ４５０氧化酶与药物氧化代谢遗传多态性的关系进行了深入的研究。有关ＣＹＰ２Ｄ６、ＣＹＰ２Ｃ１９等的突变已大多被鉴定；ＣＹＰ１Ａ１、ＣＹＰ１Ａ２等在表型存在多态性而确切的遗传机制尚不清楚。另有一些Ｐ４５０酶（如ＣＹＰ２Ａ６、ＣＹＰ２Ｃ９、ＣＹＰ２Ｅ１、ＣＹＰ３Ａ４等），在表型或基因型水平似乎存在多态性，但尚未有确切依据。本文对这些Ｐ４５０酶多态性的分子机制作了详细综述。Polymorphism has been detected in a variety of drug metabolizing enzymes at both phenotypic and genotypic level. Human cytochrome P450 enzymes have been studied extensively in recent years, and the majority of mutations which give rise to a defective phenotype have now been identified(for example CYP2D6, CYP2C19, etc.). There are some groups of enzymes showing definite polymorphism at the phenotypic level but the exact genetic mechanisms are not yet clear(CYP1A1, CYP1A2, etc.). There are still other groups of enzymes, showing some indication of polymorphism at either the phenotypic or genotypic level yet have not been unambiguously demonstrated(for example CYP2A6, CYP2C9, CYP2E1, CYP3A4, etc.). The molecular mechanism of all these polymorphisms and possible polymorphisms is discussed, with paticular reference to the effects of this variation on drug metabolism and on the susceptibility to chemically induced diseases.

关 键 词：人类 细胞色素P450 药理学 代谢 遗传多态性 

分 类 号：Q559.9[生物学—生物化学] R969.1[医药卫生—药理学]