乙丙昔罗的合成  

Synthesis of Efaproxiral

作　　者：杨辉[1] 刘明峰[1] 张嫡群[1] 杨双革[1] 赵兴茹[1] 

机构地区：[1]河北医科大学新药开发中心,河北石家庄050017

出　　处：《中国医药工业杂志》2007年第7期470-471,共2页Chinese Journal of Pharmaceuticals

摘　　要：对羟基苯乙酸与3,5-二甲基苯胺缩合得N-(3,5-二甲苯基)-2-(4-羟基苯基)乙酰胺,然后在相转移催化剂作用下与丙酮、氯仿和50%氢氧化钠溶液反应制得乙丙昔罗。总收率约61%。Efaproxiral was synthesized from p-hydroxyphenylacetic acid by condensation with 3,5-dimethylaniline to give N-（3,5-dimethylphenyl）-2-（4-hydroxyphenyl）acetamide, which was subjected to reaction with acetone, chloroform and 50% NaOH solution with an overall yield of about 61%.

关 键 词：乙丙昔罗 变构血红蛋白调节剂 抗肿瘤药 合成 

分 类 号：R979.19[医药卫生—药品]