2型糖尿病心血瘀证病证结合模型大鼠心血管指标病理改变的观察  

Cardiovascular Pathological Changes of the Rat Model of Heart Blood Stasis Syndrome in Type 2 Diabetes Mellitus

作　　者：何军锋[1] 谢梦洲[1] 田浩梅[1] 陈楚桃[1] 莫楠[1] 

机构地区：[1]湖南中医药大学,湖南长沙410007

出　　处：《中华中医药学刊》2007年第7期1365-1367,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖南省卫生厅资助项目(05C383)

摘　　要：目的:观察2型糖尿病心血瘀证病证结合大鼠模型的心血管指标的病理改变。方法:采用高脂高热量饲料喂养并结合小剂量链脲佐菌素(STZ)腹腔注射的方法制备实验性2型糖尿病大鼠模型,在此模型基础上再予强的松龙和肾上腺素注射制备2型糖尿病心血瘀证大鼠模型。结果:与其它各组比较,2型糖尿病心血瘀证模型大鼠的心脏湿重与体重的比值显著性增高(P<0.01)、心电图ST段下移幅度显著性增大(P<0.01或P<0.05)、主动脉与心肌形态学均有不同程度的病理改变。结论:2型糖尿病心血瘀证大鼠模型具有心血管病理的改变。Objective ： To observe cardiovascular pathology changes of the rat model of Heart Blood Stasis Syndrome in Type 2 Diabetes MeUitus（DM）. Methods ：Based on high fatty diet and injecting Stroptozotocin, the dexamethasone and adrenaline were applied to make the rat model of Heart Blood Stasis Syndrome in Type 2 DM. Results ：Comparing with other groups,the ratios of the heart wet weight to body weight in the model group was high significantly（ P 〈 0.01 ）, as well as ST segment of ECG descending significantly （ P 〈 0.01 or P 〈 0.05 ）, besides the pathological changes of the aorta and the heart. Conclusion ： The rat models of Heart Blood Stasis Syndrome in Type 2 DM do have the pathological changes in cardiovascular system.

关 键 词：2型糖尿病 心血瘀证 大鼠 心血管病理 

分 类 号：R285.5[医药卫生—中药学]