浅低温对急性肺损伤肺保护的研究进展  

Researching advance in the protective effects of hypothermia on acute lung injury

作　　者：汤展宏[1] 胡军涛[1] 季晓芳[1] 

机构地区：[1]广西医科大学第一附属医院外科重症监护医学中心,南宁530021

出　　处：《国际麻醉学与复苏杂志》2007年第3期228-230,234,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：急性肺损伤发病机制尚未完全阐明,目前在临床上无特效治疗方法,病死率较高。浅低温能降低机体代谢,减轻肺负担,防治呼吸机相关性肺损伤。另一方面,浅低温还能抑制中性粒细胞浸润、减少氧自由基和细胞因子释放。减少细胞凋亡、血栓形成以及降低毛细血管通透性等减轻了肺损伤。So far the pathogenesis of acute lung injury （ALI） has not been completely clarified yet. There is no specific therapy for ALI in clinic, leading to high mortality. Hypothermia may prevent and treat ventilator-associated lung injury （VALI） by decreasing body metabolism. Hypothermia lessens lung injury also by inhibiting release of many harmful cytokines （TNF- , IL-1 , IL-6 etc.） and radial oxygen species （^-OH, O2^-, H2O2 etc.）, reducing accumulation of neutrophils, decreasing cell apoptosis and thrombogenesis, and suppressing alveolar capillary permeability.

关 键 词：浅低温 急性肺损伤 肺保护 

分 类 号：R563[医药卫生—呼吸系统]