缺血／再灌注过程中信号转导通路的磷酸化调节  

Phosphoregulation of signal transduction pathways in ischemia and reperfusionl

作　　者：孙海静[1] 邹最[1] 石学银[1] 

机构地区：[1]第二军医大学长征医院麻醉科,上海200003

出　　处：《国际麻醉学与复苏杂志》2007年第3期257-259,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：器官移植、中风、心肌梗死等会引发局部缺血/再灌注（Ischemia／Reperfusion,I／R）。炎性细胞的活化和细胞毒素因子的表达与再灌注损伤密切相关。这些炎性介质的活化会启动相关下游磷酸化或去磷酸化的级联反应。该文仅综述I／R损伤过程中信号转导通路磷酸化调节机制的研究进展。Ischemia/reperfusion （I/R） injury is triggered by pathogenic processes, such as organ transplant dysfunction,stroke, and myocardial infarction. Inflammatory cell activation and cytotoxic cytokine expression are associated with reperfusion injury. The activation of these inflammatory mediators initiates several interconnected downstream cascades regulated by phosphorylation and dephosphorylation reactions. This is a review of the current understanding of the phosphoregulatory mechanisms that mediate the complex processes of signal transduction secondary to I/R injury.

关 键 词：磷酸化 缺血 再灌注 信号转导 

分 类 号：R3[医药卫生—基础医学]