钯催化下2,5-二溴噻吩与对甲氧基苯硼酸的偶合反应研究  

Study on coupling reaction between 2,5-dibromothiophene and 4-methoxylphenylboronic acid under catalysis of palladium(0)

作　　者：黄一[1] 董星[1] 郑韬[1] 何林江[1] 程晓红[1] 

机构地区：[1]教育部自然资源药物化学重点实验室,云南大学化学科学与工程学院应用化学系,云南昆明650091

出　　处：《云南大学学报（自然科学版）》2007年第4期398-400,共3页Journal of Yunnan University(Natural Sciences Edition)

基　　金：国家自然科学基金资助项目(20472070);云南省自然科学基金资助项目(2005E008M)

摘　　要：采用H2O2-HBr连用的方法对2,5-二溴噻吩的合成进行了改进,并研究了Pd(PPh3)4催化下2,5-二溴噻吩与对甲氧基苯硼酸在不同碱溶液中发生的偶合反应,采用饱和NaHCO3溶液可获得单边偶合产物Ⅰ;而采用Na2CO3溶液可获得双边偶合产物Ⅱ;采用CsCO3作为碱时,没有偶合反应发生.An impoved method for synthesis of 2,5 - bibromthiophene is reported. By using different bases in diferrent solvent, the coupling reaction between 2,5 - dibromthiophene and 4 - methoxylphenylboronic acid under the catalysis of palladium（0） provided different coupling products. The monosidecoupling product was obtained in 60% yield when NaHCO3 was used as base, doubleside coupling product was obtained when Na2CO3 was used, while no coupling product was obtained when CsCO3 was used.

关 键 词：PD催化 溴代噻吩 Suzuki偶合反应 

分 类 号：O621.25[理学—有机化学] O626.17[理学—化学]