不同尿白蛋白排泄量的2型糖尿病患者可溶性P-选择素的变化及意义  

Change and significance of serum soluble P-selectin in patients of type 2 diabetes mellitus with different urine albumin excretion

作　　者：陈兰[1] 王秋月[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2007年第12期1510-1513,共4页China Journal of Modern Medicine

摘　　要：目的观察不同尿白蛋白排泄量的2型糖尿病患者血清可溶性P-选择素的变化并探讨其意义。方法选择2型糖尿病组59例及正常对照组21例,根据24h尿白蛋白排泄量将糖尿病组分为正常白蛋白尿组(20例)、微量白蛋白尿组(19例)与临床蛋白尿组(20例)。应用酶联免疫吸附法测定各组的血清可溶性P-选择素水平。结果微量白蛋白尿组与临床蛋白尿组血清可溶性P-选择素水平均显著高于对照组,临床蛋白尿组血清可溶性P-选择素水平显著高于微量白蛋白尿组及正常白蛋白尿组,微量白蛋白尿组血清可溶性P-选择素水平显著高于正常白蛋白尿组;正常白蛋白尿组与对照组的血清可溶性P-选择素水平差异无显著性。糖尿病组的血清可溶性P-选择素水平与尿白蛋白排泄量呈显著正相关。结论尿白蛋白排泄量增加的2型糖尿病患者存在血小板活化,可溶性P-选择素可能是糖尿病肾病严重程度的预测指标。[Objective] Observe the change of serum soluble P-selectin in patients of type 2 diabetes meUitus with different urine albumin excretion to investigate the significance of this change. [Method] 59 patients with type 2 diabetes meUitus and 21 healthy control subjects were selected in this study. Patients with diabetes meUitus （DM） were subdivided into three groups according to 24 h urine albumin excretion （UAE）： normal albuminuria group, microalbuminuria group, and clinical albuminuria group. Measurement of serum soluble P-select_in （sP-selectin） was performed by ELISA. [Result] ①Compared with healthy control subjects, levels of serum sP-selecdn in microalbu- minutia group and clinical albuminuria group were significandy high. Compared with normal albuminuria group and m/croalbuminuria group, levels of serum sP-selectin in c/inical albuminuria group were significantly high. Levels of serum sP-selectin in microalbuminuria group was significantly higher than that in normal albuminuria group. There was no significant difference in levels of serum sP-selectin between normal albuminuria group and healthy control subjects. ②Levels of serum sP-selectln were positively correlated with UAE in DM patients. [Conclusion] These findings suggest that platelet activation exists in patients of type 2 diabetes mellitus with increased urine albumin excretion, sP-selectln may be an indicator of the severity of diabetic nephropathy.

关 键 词：可溶性P-选择素 尿白蛋白排泄量 2型糖尿病 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]